| The role of adipocytokines in fetal growth. | |
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MedLine Citation:
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PMID: 20840257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cumulative evidence suggests that the origins of obesity may occur during fetal development. In this respect, the concept of "developmental programming" was introduced and supported by experimental and epidemiological data. This concept supports the idea that the nutritional and hormonal status during pregnancy could irreversibly interfere in metabolism control. The mechanisms responsible for this developmental programming remain poorly documented. However, recent research indicates that adipocytokines may play a critical role in this process. Thus, leptin, adiponectin, and the recently identified resistin, visfatin, and apelin, all exert effects on fat, muscle, and liver cells early in life. The aforementioned adipocytokines are secreted by adipocytes and human placenta during fetal life and may play a major role in the etiopathogenesis of the metabolic syndrome. This review will focus on the intrauterine expression of adipocytokines, their contribution to the hormonal control of fetal growth, and their role in restricted and exaggerated intrauterine growth. |
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Authors:
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Despina D Briana; Ariadne Malamitsi-Puchner |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1205 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2010-09-28 Revised Date: 2010-10-19 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 82-7 Citation Subset: IM |
Copyright Information:
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© 2010 New York Academy of Sciences. |
Affiliation:
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Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipokines
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metabolism,
pharmacology,
physiology* Animals Female Fetal Development / drug effects, physiology* Humans Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Adipokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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