Document Detail

The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin.
MedLine Citation:
PMID:  1693646     Owner:  NLM     Status:  MEDLINE    
Interaction of T lymphocytes with other cell types is important for normal T-cell development and function. Recently, a number of adhesion molecules important in T-cell interactions with other cell types have been defined. In this paper we review the role of two adhesion pathways, CD2/LFA-3 and LFA-1/ICAM-1, in T-cell interactions with epithelial cells of the thymus and skin. While thymic epithelium-T-cell interactions were mediated by both the LFA-1/ICAM-1 pathway and the CD2/LFA-3 pathway, epidermal-T-cell interactions were mediated primarily by the LFA-1/ICAM-1 pathway. Although ICAM-1 was not expressed in vivo on epidermal keratinocytes in normal skin, ICAM-1 was expressed by epidermal keratinocytes at the site of T-cell infiltration in inflammatory dermatitis. ICAM-1 was expressed in vivo on thymic epithelium. Both LFA-3 and ICAM-1 were expressed on epithelial cells of thymus and skin early on in fetal ontogeny. These antigen-independent adhesion molecules play an important role in the cell-cell interactions associated with T-cell differentiation and function.
K H Singer; P T Le; S M Denning; L P Whichard; B F Haynes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  94     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-19     Completed Date:  1990-07-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85S-90S     Citation Subset:  IM    
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
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MeSH Terms
Antigens, CD58
Antigens, Differentiation / physiology
Antigens, Surface / physiology
Cell Adhesion Molecules / physiology*
Cell Communication*
Epidermis / metabolism
Epithelial Cells
Lymphocyte Function-Associated Antigen-1
Major Histocompatibility Complex / physiology
Membrane Glycoproteins / physiology
Receptors, Leukocyte-Adhesion / physiology
Skin / cytology*
T-Lymphocytes / cytology*
Thymus Gland / cytology*,  metabolism
Grant Support
Reg. No./Substance:
0/Antigens, CD58; 0/Antigens, Differentiation; 0/Antigens, Surface; 0/Cell Adhesion Molecules; 0/Lymphocyte Function-Associated Antigen-1; 0/Membrane Glycoproteins; 0/Receptors, Leukocyte-Adhesion

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