| The role of adenosine in the hypotensive actions of morphine. | |
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MedLine Citation:
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PMID: 8608795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of adenosine in the hypotensive action of morphine was examined in the pentobarbitone anaesthetized or pithed rat preparations. Adenosine (10-300 micrograms/kg) induced dose-dependent decreases in diastolic blood pressure in the anaesthetized rat preparation. These effects were attenuated by infusion of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX; 50 micrograms/kg/min), 8-phenyltheophylline (8PT; 50 micrograms/kg) also induced dose-dependent decreases in diastolic blood pressure. Guanethidine (16 micrograms/kg/min), atropine (1 mg/kg), DPCPX and 8 PT reduced the effect of morphine on diastolic blood pressure, whilst DMPX (50 micrograms/kg/min) was inactive. In the pithed rat preparation morphine was inactive at doses up to 10 mg/kg. The results suggest that the hypotensive effect of morphine is mediated at least in part by the release of adenosine which then acts on centrally located adenosine receptors to induce changes in autonomic control of blood pressure. |
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Authors:
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P J White; W Hope; R B Rose'Meyer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 286 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-05-28 Completed Date: 1996-05-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 315-19 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Biology and Pharmacology, Victorian College of Pharmacy, Monash University, Victoria, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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physiology* Animals Blood Pressure / drug effects* Female Guanethidine / pharmacology Morphine / pharmacology* Narcotics / pharmacology* Rats Rats, Wistar Receptors, Purinergic P1 / physiology Theobromine / analogs & derivatives, pharmacology Theophylline / analogs & derivatives, pharmacology Xanthines / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 0/Receptors, Purinergic P1; 0/Xanthines; 102146-07-6/1,3-dipropyl-8-cyclopentylxanthine; 14114-46-6/3,7-dimethyl-1-propargylxanthine; 55-65-2/Guanethidine; 57-27-2/Morphine; 58-55-9/Theophylline; 58-61-7/Adenosine; 80206-91-3/8-(4-sulfophenyl)theophylline; 83-67-0/Theobromine |
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