| The role of activation-induced cytidine deaminase (AID/AICDA) in the progression of follicular lymphoma. | |
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MedLine Citation:
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PMID: 22168746 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Activation-induced cytidine deaminase (AID/AICDA) is required for somatic hyper-mutation and class-switch recombination of the immunoglobulin gene, and for c-myc translocation of germinal center-derived B-cell lymphoma. In the present study, we attempted to clarify the significance of AID associated with c-myc in the progression of follicular lymphoma (FL) using RT-PCR and quantitative real-time PCR. Tissues from the patients with grade 3 FL expressed relatively higher levels of c-myc and AID. Interestingly, The samples taken from a patient with FL who died within two years after the start of treatment, showed either no or low expression of AID, despite expressing high levels of c-myc. In order to examine the role of AID expression in rapidly progressive FL, the full-length AID transcript was transfected into AID-negative cell lines established from different patients with rapidly progressive FL. This led to the establishment of AID-expressing transfectants exhibiting a low proliferation rate and a significantly increased incidence of G0/G1 arrest in comparison with controls. Our results indicate that AID may act as a negative regulator of cell survival in FL when sufficient c-myc is expressed. Switch-off or low expression of AID after c-myc amplification may correlate with the clinical outcomes of FL. © 2011 Japanese Cancer Association. |
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Authors:
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Hisaharu Shikata; Yoshihiro Yakushijin; Natsuki Matsushita; Akira Sakai; Atsuro Sugita; Naoya Nakamura; Jun Yamanouchi; Taichi Azuma; Takaaki Hato; Masaki Yasukawa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-15 |
Journal Detail:
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Title: Cancer science Volume: - ISSN: 1349-7006 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168776 Medline TA: Cancer Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Japanese Cancer Association. |
Affiliation:
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Department of Bioregulatory Medicine Cancer Center Department of Pathology Division of Blood Transfusion and Cell Therapy, Ehime University Hospital, Ehime University Graduate School of Medicine, Toon, Japan Functional Genomics Core Laboratory, Ehime University Proteo-medicine Research Center, Toon, Japan Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University Graduate School of Medicine, Hiroshima, Japan Department of Pathology, Tokai University School of Medicine, Isehara, Japan. |
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