Document Detail

A role for TonB1 in biofilm formation and quorum sensing in Pseudomonas aeruginosa.
MedLine Citation:
PMID:  17623027     Owner:  NLM     Status:  MEDLINE    
This study revealed that a Pseudomonas aeruginosa tonB1 mutant was unable to produce a mature biofilm and showed reduced swarming and twitching motilities compared with the parent strain. The tonB1 mutant was also found to produce significantly lower cell-free and cell-associated levels of the quorum sensing (QS) signal molecule 3-oxo-C12-AHL. Altered biofilm and motility phenotypes were restored to wildtype with the addition of exogenous N-acylhomoserine lactones. These functions were independent of the role of TonB1 in iron uptake. This is the first time that a link has been established between TonB1 activity and QS.
Abdelhamid Abbas; Claire Adams; Norma Scully; Jeremy Glennon; Fergal O'Gara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-09
Journal Detail:
Title:  FEMS microbiology letters     Volume:  274     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-78     Citation Subset:  IM    
Microbiology Department, National University of Ireland, Cork, Ireland.
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MeSH Terms
4-Butyrolactone / analogs & derivatives,  biosynthesis
Biofilms / growth & development*
Escherichia coli Proteins / metabolism
Gene Expression Regulation, Bacterial
Membrane Proteins / metabolism
Pseudomonas aeruginosa / genetics,  physiology*
Quorum Sensing / physiology*
Signal Transduction / physiology*
Reg. No./Substance:
0/Escherichia coli Proteins; 0/Membrane Proteins; 0/tonB protein, E coli; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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