| The role of T regulatory cells in human sepsis. | |
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MedLine Citation:
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PMID: 19345068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well-known that septic shock undermines immune homeostasis by inducing an initial intense systemic inflammatory response that is rapidly followed by a negative feedback of anti-inflammatory process. This secondary immunoparalysis state is characterized by decreased phagocytic cells, T cells, natural killer cells and B cells function and proinflammatory cytokine release. This persistence of immunoparalysis increased the risk for fatal outcome. In recent studies it was found that following the onset of septic shock, a relative increase in T regulatory cells number and suppressive function appears and makes them an important participant in the inhibition of immune responsiveness during sepsis. Consequently, a question emerging from these findings concerns the degree to which the manipulation of T regulatory cells might improve the outcome of patients with sepsis. Preliminary studies in animal models suggest that more work is needed to understand the conditions under which such a therapy may be effective. |
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Authors:
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Aharon Kessel; Ellen Bamberger; Muhamad Masalha; Elias Toubi |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-04-03 |
Journal Detail:
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Title: Journal of autoimmunity Volume: 32 ISSN: 1095-9157 ISO Abbreviation: J. Autoimmun. Publication Date: 2009 May-Jun |
Date Detail:
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Created Date: 2009-05-08 Completed Date: 2009-07-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8812164 Medline TA: J Autoimmun Country: England |
Other Details:
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Languages: eng Pagination: 211-5 Citation Subset: IM |
Affiliation:
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Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD / immunology, metabolism Cytokines / immunology*, metabolism Forkhead Transcription Factors / immunology, metabolism Humans Immune Tolerance / immunology Sepsis / immunology*, metabolism Shock, Septic / immunology, metabolism T-Lymphocytes, Regulatory / immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Cytokines; 0/Forkhead Transcription Factors; 0/cytotoxic T-lymphocyte antigen 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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