Document Detail


The role of the T-cell receptor in thymocyte maturation: effects in vivo of anti-receptor antibody.
MedLine Citation:
PMID:  3095843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The T-cell receptor, which recognizes antigen plus a product of the major histocompatibility complex, has been postulated to drive T-cell maturation in the thymus by engaging major histocompatibility complex proteins expressed on thymic stromal cells. We tested this idea by injecting neonatal animals with an anti-receptor antibody, KJ16, that binds to about 20% of T cells and is capable of blocking receptor function. In the presence of this antibody, mature T cells bearing the KJ16 epitope failed to develop. On the other hand, although the antibody could be shown to bind to receptors on cortical thymocytes, it did not prevent the rapid expansion or survival of the bulk of the KJ16+ cells in this population. These results are consistent with the hypothesis that most cortical thymocytes arise by a receptor-independent mechanism and that only a small proportion of these cells mature by a process dependent on receptor-major histocompatibility complex interactions.
Authors:
M McDuffie; W Born; P Marrack; J Kappler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  83     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-17     Completed Date:  1986-12-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8728-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / immunology*
Cell Differentiation
Immunoglobulin Fab Fragments / immunology
Kinetics
Major Histocompatibility Complex
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Pepsin A / pharmacology
Receptors, Antigen, T-Cell / immunology,  physiology*
T-Lymphocytes / physiology*
Grant Support
ID/Acronym/Agency:
AI-00048/AI/NIAID NIH HHS; AI-17134/AI/NIAID NIH HHS; AI-18785/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Immunoglobulin Fab Fragments; 0/Receptors, Antigen, T-Cell; EC 3.4.23.1/Pepsin A
Comments/Corrections

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