Document Detail

The role of Sp1 and Sp3 in normal and cancer cell biology.
MedLine Citation:
PMID:  20810260     Owner:  NLM     Status:  MEDLINE    
Sp1 and Sp3 are transcription factors expressed in all mammalian cells. These factors are involved in regulating the transcriptional activity of genes implicated in most cellular processes. Dysregulation of Sp1 and Sp3 is observed in many cancers and diseases. Due to the amino acid sequence similarity of the DNA binding domains, Sp1 and Sp3 recognize and associate with the same DNA element with similar affinity. However, others and our laboratory demonstrated that these two factors possess different properties and exert different functional roles. Both Sp1 and Sp3 can interact with and recruit a large number of proteins including the transcription initiation complex, histone modifying enzymes and chromatin remodeling complexes, which strongly suggest that Sp1 and Sp3 are important transcription factors in the remodeling chromatin and the regulation of gene expression. In this review, the role of Sp1 and Sp3 in normal and cancer cell biology and the multiple mechanisms deciding the functional roles of Sp1 and Sp3 will be presented.
Lin Li; James R Davie
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-08-06
Journal Detail:
Title:  Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft     Volume:  192     ISSN:  1618-0402     ISO Abbreviation:  Ann. Anat.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-17     Completed Date:  2010-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963897     Medline TA:  Ann Anat     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  275-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier GmbH. All rights reserved.
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada.
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MeSH Terms
Chromatin Assembly and Disassembly
DNA-Binding Proteins / chemistry,  metabolism
Gene Expression Regulation, Neoplastic
Sp1 Transcription Factor / chemistry,  metabolism*,  physiology
Sp3 Transcription Factor / chemistry,  metabolism*,  physiology
Transcription, Genetic
Transcriptional Activation
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Sp1 Transcription Factor; 148710-94-5/Sp3 Transcription Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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