| The role of Smad4 in vestibular development in mice. | |
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MedLine Citation:
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PMID: 20969946 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The regulation of the bone morphogenetic protein (BMP) signal transduction pathway is important in the development of the inner ear and vestibular system. We reported previously that small mothers against decapentaplegic homolog-4 (Smad4) is required for inner ear cochlear development and normal auditory function in mammals; however, the distribution and functional mechanisms of Smad4 at various stages of vestibular development remained unclear. To investigate the relationship between the Smad4 gene and vestibular organ development, we measured changes in the expression of BMP4 and Smad4 during vestibular development in C57BL/6 mice. In addition, vestibular structures, pathologic changes, and the vestibular function of chondrocyte-specific Smad4 knockout mice were compared to those of the control group. We found that the expression of Smad4 in the inner ear was delayed compared with that of BMP4. Moreover, chondrocyte-specific Smad4 knockout homozygous mice showed stunted growth and partial vestibular deformities, but it showed less histologic changes in the vestibular end-organs and saccule dysfunction. These results suggest that Smad4 participates in late-stage shaping of the configuration of the vestibule and development of vestibular functional, but a Smad4-independent pathway for the inner ear vestibular BMP4 signal transduction could not be rule out. |
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Authors:
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Shi-ming Yang; An-chun Deng; De-liang Huang; Jian-he Sun; Guan Yang; Ya-ping Yu; Zhao-hui Hou; Wei-wei Guo; Suo-qiang Zhai; David Z Z He; Dong-yi Han; Wie-yen Young; Xiao Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-20 |
Journal Detail:
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Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience Volume: 29 ISSN: 1873-474X ISO Abbreviation: Int. J. Dev. Neurosci. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2010-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8401784 Medline TA: Int J Dev Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 15-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 ISDN. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, PR China. yangsm301@263.net |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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