Document Detail


The role of SIRT1 in tumorigenesis.
MedLine Citation:
PMID:  22180829     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
NAD-dependent Class III histone deacetylase SIRT1 is a multiple functional protein and has been demonstrated critically involved in stress response, cellular metabolism and aging through deacetylating variety of substrates including p53, forkhead transcription factors, PGC-1α, NF-κB, Ku70 and histones. Increasing evidences indicate that SIRT1 plays a complex role in tumorigenesis with functions in both tumor promoting and tumor suppressing. This review provides an overview of current knowledge of SIRT1 and its controversies regarding the functions of SIRT1 in tumorigenesis.
Authors:
Kai Li; Jianyuan Luo
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  North American journal of medicine & science     Volume:  4     ISSN:  2156-2342     ISO Abbreviation:  -     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531232     Medline TA:  N A J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  104-106     Citation Subset:  -    
Affiliation:
Department of Medical & Research Technology, Department of Pathology, School of Medicine, University of Maryland, AHB 405A, 100 Penn Street, Baltimore, MD 21201.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 AG026534-01A2//NIA NIH HHS

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