Document Detail

A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility.
MedLine Citation:
PMID:  19020613     Owner:  NLM     Status:  MEDLINE    
The kidney has an important role in the regulation of acid-base homeostasis. Renal ammonium production and excretion are essential for net acid excretion under basal conditions and during metabolic acidosis. Ammonium is secreted into the urine by the collecting duct, a distal nephron segment where ammonium transport is believed to occur by non-ionic NH(3) diffusion coupled to H(+) secretion. Here we show that this process is largely dependent on the Rhesus factor Rhcg. Mice lacking Rhcg have abnormal urinary acidification due to impaired ammonium excretion on acid loading-a feature of distal renal tubular acidosis. In vitro microperfused collecting ducts of Rhcg(-/-) acid-loaded mice show reduced apical permeability to NH(3) and impaired transepithelial NH(3) transport. Furthermore, Rhcg is localized in epididymal epithelial cells and is required for normal fertility and epididymal fluid pH. We anticipate a critical role for Rhcg in ammonium handling and pH homeostasis both in the kidney and the male reproductive tract.
Sophie Biver; Hendrica Belge; Soline Bourgeois; Pascale Van Vooren; Marta Nowik; Sophie Scohy; Pascal Houillier; Josiane Szpirer; Claude Szpirer; Carsten A Wagner; Olivier Devuyst; Anna Maria Marini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  456     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2008-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  339-43     Citation Subset:  IM    
Université Libre de Bruxelles (U.L.B.), Institut de Biologie et de Médecine Moléculaires, Laboratoire de Biologie du Développement, Gosselies, Belgium.
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MeSH Terms
Acidosis / physiopathology
Acids / metabolism
Biological Transport
Body Fluids
Cation Transport Proteins / deficiency,  genetics,  metabolism*
Epithelial Cells / metabolism
Fertility / physiology*
Gene Deletion
Genitalia, Male / cytology,  metabolism
Hydrogen-Ion Concentration
Kidney / physiology*
Kidney Tubules, Collecting / physiology
Kidney Tubules, Distal / physiology
Membrane Glycoproteins / deficiency,  genetics,  metabolism*
Quaternary Ammonium Compounds / urine*
Stress, Physiological
Weight Loss
Reg. No./Substance:
0/Acids; 0/Cation Transport Proteins; 0/Membrane Glycoproteins; 0/Quaternary Ammonium Compounds; 0/Rhcg protein, mouse
Comment In:
Nature. 2008 Nov 20;456(7220):336-7   [PMID:  19020610 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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