| A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility. | |
| | |
MedLine Citation:
|
PMID: 19020613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The kidney has an important role in the regulation of acid-base homeostasis. Renal ammonium production and excretion are essential for net acid excretion under basal conditions and during metabolic acidosis. Ammonium is secreted into the urine by the collecting duct, a distal nephron segment where ammonium transport is believed to occur by non-ionic NH(3) diffusion coupled to H(+) secretion. Here we show that this process is largely dependent on the Rhesus factor Rhcg. Mice lacking Rhcg have abnormal urinary acidification due to impaired ammonium excretion on acid loading-a feature of distal renal tubular acidosis. In vitro microperfused collecting ducts of Rhcg(-/-) acid-loaded mice show reduced apical permeability to NH(3) and impaired transepithelial NH(3) transport. Furthermore, Rhcg is localized in epididymal epithelial cells and is required for normal fertility and epididymal fluid pH. We anticipate a critical role for Rhcg in ammonium handling and pH homeostasis both in the kidney and the male reproductive tract. |
| | |
Authors:
|
Sophie Biver; Hendrica Belge; Soline Bourgeois; Pascale Van Vooren; Marta Nowik; Sophie Scohy; Pascal Houillier; Josiane Szpirer; Claude Szpirer; Carsten A Wagner; Olivier Devuyst; Anna Maria Marini |
Related Documents
:
|
4001903 - Urolithiasis in railroad shopmen in relation to oxalic acid exposure at work. 7249373 - Deficiency of fumarylacetoacetase in a patient with hereditary tyrosinemia. 16666393 - Inhibition of ethylene biosynthesis by salicylic acid. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Nature Volume: 456 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2008-11-21 Completed Date: 2008-12-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
|
Languages: eng Pagination: 339-43 Citation Subset: IM |
Affiliation:
|
Université Libre de Bruxelles (U.L.B.), Institut de Biologie et de Médecine Moléculaires, Laboratoire de Biologie du Développement, Gosselies, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acidosis
/
physiopathology Acids / metabolism Animals Biological Transport Body Fluids Cation Transport Proteins / deficiency, genetics, metabolism* Epithelial Cells / metabolism Fertility / physiology* Gene Deletion Genitalia, Male / cytology, metabolism Homeostasis Hydrogen-Ion Concentration Kidney / physiology* Kidney Tubules, Collecting / physiology Kidney Tubules, Distal / physiology Male Membrane Glycoproteins / deficiency, genetics, metabolism* Mice Permeability Quaternary Ammonium Compounds / urine* Stress, Physiological Weight Loss |
| Chemical | |
Reg. No./Substance:
|
0/Acids; 0/Cation Transport Proteins; 0/Membrane Glycoproteins; 0/Quaternary Ammonium Compounds; 0/Rhcg protein, mouse |
| Comments/Corrections | |
Comment In:
|
Nature. 2008 Nov 20;456(7220):336-7
[PMID:
19020610
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High diversity of cultivable heterotrophic bacteria in association with cyanobacterial water blooms.
Next Document: Identification of Holliday junction resolvases from humans and yeast.