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The role of Panton-Valentine leukocidin in Staphylococcus aureus musculoskeletal infections in children.
MedLine Citation:
PMID:  22327874     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Infections caused by Pantone-Valentine leukocidin (PVL)-producing strains of Staphylococcus aureus have been reported with increasing frequency. However, the role of PVL in the pathogenesis of invasive staphylococcal infection is controversial. Interestingly, the role played by PVL may depend on the site of infection; whilst an association between PVL and severity has been reported in lung and bone infection, this is not the case for skin and soft tissue infection. A number of recent reports describe severe complications associated with PVL production in musculoskeletal infections. This review summarises the current evidence on the influence of PVL on musculoskeletal infections caused by S. aureus in children and highlights areas of uncertainty relating to management.
Authors:
Nicole Ritz; Nigel Curtis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-9
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Paediatrics, The University of Melbourne and Infectious Diseases Unit, Department of General Medicine; and Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Parkville, Australia 2Infectious Diseases Unit, University Children's Hospital Basel, Switerzland.
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