| The role of P-glycoprotein in human gastric cancer xenografts in response to chemotherapy. | |
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MedLine Citation:
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PMID: 11817335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To clarify the contribution of P-glycoprotein (P-GP) to drug resistance of gastric cancer, the correlation between chemosensitivity of the tumor and expression of P-GP was examined using human gastric cancer xenografts in nude mice. METHODS: Two strains, P-GP-positive and -negative, were established using primary explants from patients who had not received chemotherapy. Their stable growth was obtained by serial passages as subcutaneous tumors in nude mice. Mitomycin C (MMC, 3.25 mg/kg), adriamycin (ADR, 6mg/kg), or cisplatin (CDDP, 6mg/kg) was administered intraperitoneally once a week for 3 weeks. RESULTS: In the P-GP-negative strain, all three drugs significantly suppressed the tumor growth, while in the P-GP-positive strain, only MMC did so. However, the growth inhibition of MMC was apparently greater in the P-GP-negative strain than in the positive tumor. The expressions of metallothionein (MT), glutathione-S-transferase-pi (GST-pi), and p53 were not different between the strains. Bcl-2 was expressed only in the P-GP-negative strain. Induction of P-GP expression was observed in some specimens after treatment with MMC and with CDDP. CONCLUSIONS: P-GP might affect inherent and acquired resistance against chemotherapeutic agents in gastric cancer. |
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Authors:
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N Monden; S Abe; Y Hishikawa; H Yoshimura; S Kinugasa; D K Dhar; M Tachibana; N Nagasue |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of surgical investigation Volume: 1 ISSN: 1028-5229 ISO Abbreviation: Int. J. Surg. Investig. Publication Date: 1999 |
Date Detail:
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Created Date: 2001-12-05 Completed Date: 2002-01-30 Revised Date: 2006-07-25 |
Medline Journal Info:
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Nlm Unique ID: 100965774 Medline TA: Int J Surg Investig Country: England |
Other Details:
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Languages: eng Pagination: 3-10 Citation Subset: IM |
Affiliation:
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The Second Department of Surgery, Shimane Medical University, Izumo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibiotics, Antineoplastic / therapeutic use* Antineoplastic Agents / therapeutic use* Cisplatin / therapeutic use* Doxorubicin / therapeutic use* Humans Injections, Intraperitoneal Mice Mice, Inbred BALB C Mice, Nude Mitomycin / therapeutic use* Mutation Neoplasm Transplantation P-Glycoprotein / physiology* Stomach Neoplasms / drug therapy*, physiopathology* Transplantation, Heterologous Tumor Suppressor Protein p53 / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Antineoplastic Agents; 0/P-Glycoprotein; 0/Tumor Suppressor Protein p53; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin; 50-07-7/Mitomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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