Document Detail


The role of the ORL1 receptor in the modulation of spinal neurotransmission by nociceptin/orphanin FQ and nocistatin.
MedLine Citation:
PMID:  11166734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nociceptin/orphanin FQ and nocistatin are two neuropeptides with opposing effects on spinal neurotransmission and nociception. Nociceptin/orphanin FQ selectively suppresses excitatory glutamatergic neurotransmission, while nocistatin selectively interferes with glycinergic and gamma-aminobutyric acid (GABA)-ergic transmission. Here, we performed whole-cell patch-clamp recordings from superficial rat spinal cord dorsal horn neurons to investigate the role of the opioid receptor-like (ORL)1 receptor for modulatory actions of these peptides. The partial ORL1 receptor antagonist [phe1psi(CH(2)-NH)Gly(2)]nociceptin-(1-13)NH(2) competitively reversed the effects of nociceptin/orphanin FQ on excitatory neurotransmission (estimated pA(2) 6.43), but left the suppression of inhibitory synaptic transmission by nocistatin unaffected. These results indicate that the inhibitory action of nociceptin/orphanin FQ on glutamatergic transmission is mediated via ORL1 receptors, while nocistatin acts via a different so far unidentified receptor.
Authors:
S Ahmadi; J T Liebel; H U Zeilhofer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  412     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2002-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Affiliation:
Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität Erlangen-Nürnberg, Fahrstrasse 17, D-91054, Erlangen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Opioid / pharmacology*
Animals
Excitatory Postsynaptic Potentials / drug effects,  physiology
Female
Male
Opioid Peptides / pharmacology*
Posterior Horn Cells / drug effects*,  physiology
Rats
Rats, Sprague-Dawley
Receptors, Opioid / drug effects*,  physiology
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 0/Opioid Peptides; 0/Receptors, Opioid; 0/Vasodilator Agents; 0/nociceptin; 0/nociceptin receptor; 0/nocistatin

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