Document Detail

A role for NPC1 and NPC2 in intestinal cholesterol absorption--the hypothesis gutted.
MedLine Citation:
PMID:  17956226     Owner:  NLM     Status:  MEDLINE    
Dietary and biliary cholesterol are taken up by intestinal epithelial cells and transported to the endoplasmic reticulum. At the endoplasmic reticulum, cholesterol is esterified, packaged into chylomicrons and secreted into the lymph for delivery to the bloodstream. NPC1L1 (Niemann-Pick C1-like 1) is a protein on the enterocyte brush-border membrane that facilitates cholesterol absorption. Cholesterol's itinerary as it moves to the endoplasmic reticulum is unknown, as is the identity of any cellular proteins that facilitate the movement. Two proteins that play an important role in intracellular cholesterol transport and could potentially influence NPC1L1-mediated cholesterol uptake are NPC1 and NPC2 (Niemann-Pick type C disease proteins 1 and 2). In this issue of the Biochemical Journal, Dixit and colleagues show that the absence or presence of NPC1 and NPC2 has no effect on intestinal cholesterol absorption in the mouse. Thus neither protein fills the gap in our knowledge of intra-enterocyte cholesterol transport. Furthermore, the NPC1/NPC2 pathway would not be a good target for limiting the uptake of dietary cholesterol.
Laura Liscum
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  408     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-24     Completed Date:  2007-11-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  England    
Other Details:
Languages:  eng     Pagination:  e1-3     Citation Subset:  IM    
Department of Physiology, Tufts University School of Medicine, Boston, MA 02111, USA.
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MeSH Terms
Biological Markers
Carrier Proteins / metabolism*
Cholesterol / metabolism*
Intestinal Absorption*
Membrane Glycoproteins / metabolism*
Niemann-Pick Diseases / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Carrier Proteins; 0/Membrane Glycoproteins; 57-88-5/Cholesterol
Comment On:
Biochem J. 2007 Nov 15;408(1):1-5   [PMID:  17880278 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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