Document Detail

The role of NO in ischemia/reperfusion injury in isolated rat heart.
MedLine Citation:
PMID:  16474186     Owner:  NLM     Status:  MEDLINE    
IN CONCLUSION: our results indicate that administration of L-NAME might be cardioprotective in the normal hearts exposed to ischemia/reperfusion (I/R) alone, suggesting that NO contributes to low ischemic tolerance in the non-adapted hearts. On the other hand, blockade of cardioprotective effect of IP by L-NAME points out to a dual role of NO in the heart: a negative role in the non-adapted myocardium subjected to I/R, and a positive one, due to its involvement in the mechanisms of protection triggered by short-term cardiac adaptation by preconditioning.
E Andelová; M Barteková; D Pancza; J Styk; T Ravingerová
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General physiology and biophysics     Volume:  24     ISSN:  0231-5882     ISO Abbreviation:  Gen. Physiol. Biophys.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-02-13     Completed Date:  2006-04-18     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  8400604     Medline TA:  Gen Physiol Biophys     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  411-26     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / etiology,  physiopathology*
Blood Flow Velocity
Blood Pressure
Coronary Circulation
Myocardial Contraction*
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / metabolism*
Nitric Oxide Synthase / antagonists & inhibitors,  metabolism*
Rats, Wistar
Reperfusion Injury / complications,  physiopathology*
Ventricular Dysfunction, Left / etiology,  physiopathology*
Reg. No./Substance:
31C4KY9ESH/Nitric Oxide; EC Oxide Synthase; V55S2QJN2X/NG-Nitroarginine Methyl Ester

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