Document Detail


The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury.
MedLine Citation:
PMID:  21228168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, promotes survival and synaptic plasticity in the human brain. The Val66Met polymorphism of the BDNF gene interferes with intracellular trafficking, packaging, and regulated secretion of this neurotrophin. The human prefrontal cortex (PFC) shows lifelong neuroplastic adaption implicating the Val66Met BDNF polymorphism in the recovery of higher-order executive functions after traumatic brain injury (TBI). In this study, we examined the effect of this BDNF polymorphism on the recovery of executive functioning after TBI. We genotyped a sample of male Vietnam combat veterans consisting of a frontal lobe lesion group with focal penetrating head injuries and a non-head-injured control group for the Val66Met BDNF polymorphism. The Delis-Kaplan Executive Function System as a standardized psychometric battery was administrated to examine key domains of executive functions. The results revealed that the Met allele but not the hypothesized Val allele promotes recovery of executive functioning. Overall, the Met66 carriers in the lesion group performed as well as the Met66 carriers in the control group. The Met66 allele accounted for 6.2% of variance for executive functioning independently of other significant predictors including preinjury intelligence, left hemisphere volume loss, and dorsolateral PFC volume loss. The findings point to different mechanisms of the Val66Met BDNF gene in complex phenotypes under normal and pathological conditions. A better understanding of these mechanisms could be instrumental in the development and application of effective therapeutic strategies to facilitate recovery from TBI.
Authors:
Frank Krueger; Matteo Pardini; Edward D Huey; Vanessa Raymont; Jeffrey Solomon; Robert H Lipsky; Colin A Hodgkinson; David Goldman; Jordan Grafman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  31     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-13     Completed Date:  2011-02-22     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  598-606     Citation Subset:  IM    
Affiliation:
Department of Molecular Neuroscience, George Mason University, Fairfax, Virginia 22030, USA. fkrueger@gmu.edu
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MeSH Terms
Descriptor/Qualifier:
Brain Injuries / metabolism,  pathology,  physiopathology*
Brain-Derived Neurotrophic Factor / genetics,  physiology*
Frontal Lobe / injuries,  pathology
Humans
Linear Models
Male
Methionine / genetics
Middle Aged
Polymorphism, Genetic
Recovery of Function
Valine / genetics
Veterans
War
Wounds, Penetrating / metabolism,  pathology,  physiopathology*
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 63-68-3/Methionine; 7004-03-7/Valine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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