| The role of MRI in the intestinal complications in cystic fibrosis. | |
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MedLine Citation:
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PMID: 11682294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibrosing colonopathy is a complication recently detected in children with cystic fibrosis (CF), and is thought to be associated with the use of high-strength pancreatic enzymes. The goal of this study was to evaluate the effectiveness of magnetic resonance (MR) in detecting possible pathologic gut findings in patients with CF under pancreatic enzyme treatment. Twenty-five patients with CF and pancreatic insufficiency, all under treatment with high-dose pancreatic enzymes, were studied by MR. MR was performed on a 1.5-T magnet by T1-weighted, 2D-FLASH fat-suppression, breath-hold sequences before and after intravenous administration of gadolinium, and by T2-weighted Turbo Spin-Echo (TSE) and Half-Fourier Acquisition Single-Shot Turbo Spin Echo (HASTE) fat-suppression, breath-hold sequences. A superparamagnetic negative oral contrast agent was given 1.5 h before the examination. MR showed a wall thickening of the terminal ileum and the ascending colon (>4-12 mm) in 22 patients; nine of them (wall thickness >4-6 mm) showed both a moderate hyperintensity of the bowel wall on T2-weighted sequences and an enhancement after intravenous gadolinium on T1-weighted sequences; 13 patients (wall thickness >6-12 mm) showed both a great wall enhancement after intravenous gadolinium and an increased signal intensity of the bowel wall on T2-weighted sequences. Fecal impaction without bowel wall involvement was detected in three patients. MR proved to be a useful, noninvasive, diagnostic tool for the evaluation of patients with CF and fibrosing colonopathy. The signal hyperintensity on T2-weighted sequences and the great wall enhancement after intravenous gadolinium administration indicating an acute edematous condition, provide the clinicians useful information for the therapeutic adjustment. |
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Authors:
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M Almberger; E Iannicelli; M Antonelli; M Matrunola; G Cimino; R Passariello |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical imaging Volume: 25 ISSN: 0899-7071 ISO Abbreviation: Clin Imaging Publication Date: 2001 Sep-Oct |
Date Detail:
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Created Date: 2001-10-29 Completed Date: 2001-12-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8911831 Medline TA: Clin Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 344-8 Citation Subset: IM |
Affiliation:
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Department of Radiology, University La Sapienza, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Contrast Media Cystic Fibrosis / complications*, drug therapy Enzymes / administration & dosage, adverse effects Exocrine Pancreatic Insufficiency / drug therapy, etiology Female Gadolinium DTPA / diagnostic use Humans Intestinal Diseases / diagnosis*, etiology Magnetic Resonance Imaging / methods* Male |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Enzymes; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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