Document Detail

The role of Lewis acid-base processes in ligand-exchange chromatography of benzoic acid derivatives on zirconium oxide.
MedLine Citation:
PMID:  1621999     Owner:  NLM     Status:  MEDLINE    
Porous microparticulate zirconium oxide shows very different selectivities and pH dependencies for the separation of benzoic acid derivatives than do conventional bonded-phase anion-exchange supports. This results from a very significant ligand-exchange contribution to the retention of hard Lewis bases on the surface of transition-metal oxide supports. We have found that the capacity factors of a wide variety of derivatives of benzoic acid are closely correlated with their Bronsted acidities. The eluent pH is also a critical factor in determining the magnitude of the capacity factor, but it does not have much influence on chromatographic selectivity. The differential selectivity of this phase in comparison to conventional polymeric and bonded-phase anion exchangers can be attributed to complexation and steric effects which profoundly alter the elution patterns of certain solutes.
J A Blackwell; P W Carr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Analytical chemistry     Volume:  64     ISSN:  0003-2700     ISO Abbreviation:  Anal. Chem.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-08-04     Completed Date:  1992-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  853-62     Citation Subset:  IM    
Group Analytical Laboratory, Specialty Adhesives and Chemicals Division, 3M Company, St. Paul, Minnesota 55144-1000.
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MeSH Terms
Benzoates / analysis*,  chemistry
Benzoic Acid
Chromatography, Ion Exchange*
Hydrogen-Ion Concentration
Zirconium / chemistry*
Reg. No./Substance:
0/Benzoates; 1314-23-4/zirconium oxide; 65-85-0/Benzoic Acid; 7440-67-7/Zirconium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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