Document Detail

The role of IgM antibodies in the recognition and clearance of apoptotic cells.
MedLine Citation:
PMID:  15829266     Owner:  NLM     Status:  MEDLINE    
Apoptotic cells not only translocate phosphatidylserine to the outside of the membrane, they activate phospholipases that remodel their membranes resulting in the exposure and diffusion of altered phospholipids. These altered phospholipids include lysophosphotidylcholine (LPC) that is a ligand for CRP and is also antigenic for natural IgM antibodies. Furthermore, soluble LPC acts as a "find me" signal to attract phagocytes to migrate toward apoptotic cells. IgM mediated opsonization of apoptotic cells with complement accelerates their clearance by phagocytic cells. Failure to rapidly remove apoptotic cells on the other hand, allows dying cells to undergo post-apoptotic necrosis and inflammation. Natural antibodies therefore provide a previously unrecognized role in prevention of autoimmunity.
YuFeng Peng; Robert Kowalewski; SunJung Kim; Keith B Elkon
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2005-01-16
Journal Detail:
Title:  Molecular immunology     Volume:  42     ISSN:  0161-5890     ISO Abbreviation:  Mol. Immunol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-14     Completed Date:  2005-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905289     Medline TA:  Mol Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  781-7     Citation Subset:  IM    
Division of Rheumatology, University of Washington, P.O. Box 356428, 1959 NE Pacific Street, Seattle, WA 98195-6428, USA.
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MeSH Terms
Acute-Phase Proteins / immunology
Apoptosis / immunology*
Immunoglobulin M / immunology*
Lysophosphatidylcholines / immunology
Macrophages / immunology
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Immunoglobulin M; 0/Lysophosphatidylcholines

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