| The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. | |
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MedLine Citation:
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PMID: 21058922 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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IMPORTANCE OF THE FIELD: The insulin-resistant conditions of type 2 diabetes mellitus (T2DM) and obesity are a major cause of cardiovascular disease on a global scale. These disorders are not only a cause of ill health but are a huge financial drain on healthcare systems. T2DM leads to an increased risk of cardiovascular mortality equivalent to over 10 years of ageing while obesity independent of T2DM also leads to a substantially increased risk of acute myocardial infarction. Recent trials of therapeutic agents and approaches to preventing the cardiovascular complications of type 2 diabetes have been disappointing. AREAS COVERED IN THIS REVIEW: The role of insulin resistance in the endothelium in the regulation of the anti-atherosclerotic signalling molecule NO and a potential important role for IGF-1 in vascular NO production. WHAT THE READER WILL GAIN: A comprehensive understanding of how insulin and IGF-1 regulate vascular function and the effect of type 2 diabetes on these pathways. TAKE HOME MESSAGE: The roles of insulin and IGF-1 in vascular function are complex and intimately related. Nevertheless IGF-1 signalling in the arterial wall has the potential to be manipulated to protect the vasculature against the development of atherosclerosis and its devastating complications. |
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Authors:
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Victoria K Gatenby; Mark T Kearney |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Expert opinion on therapeutic targets Volume: 14 ISSN: 1744-7631 ISO Abbreviation: Expert Opin. Ther. Targets Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101127833 Medline TA: Expert Opin Ther Targets Country: England |
Other Details:
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Languages: eng Pagination: 1333-42 Citation Subset: IM |
Affiliation:
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University of Leeds Multidisciplinary Cardiovascular Research Centre, Leeds, UK. |
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| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation; //Medical Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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