| The role of HBsAg quantification for monitoring natural history and treatment outcome. | |
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MedLine Citation:
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PMID: 23286856 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Since its discovery by Blumberg in 1965, the hepatitis B virus antigen (HBsAg) is used as the fingerprint of hepatitis B infection. The HBsAg level is a reflection of the transcriptional activity of cccDNA. It is an important marker that not only indicates active hepatitis B infection but can also predict clinical and treatment outcomes. Assays for HBsAg quantification are fully automated and have high output. HBsAg titres are higher in HBe antigen (HBeAg)(+) than in HBeAg(-) patients and are negatively correlated with liver fibrosis in HBeAg(+) patients. In HBeAg(-) chronic hepatitis B, an HBsAg level <1000 IU/ml and an HBV DNA titre <2000 IU/ml accurately identify inactive carriers. During PEG-IFN treatment, HBsAg quantification is used to identify patients who will not benefit from therapy as early as week 12 on therapy, so that treatment may be stopped or switched- 'week 12 stopping rule'. With nucleos(t)ide analogues (NA), the role of HBsAg quantification must be clarified. Several studies show that baseline and on-treatment HBsAg levels might identify patients that can be treated with no subsequent risk of reactivation. In clinical practice, HBsAg quantification is a simple and reproducible tool that can be used in association with HBV DNA to classify patients during the natural history of HBV and to monitor therapy. |
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Authors:
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Michelle Martinot-Peignoux; Martine Lapalus; Tarik Asselah; Patrick Marcellin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Liver international : official journal of the International Association for the Study of the Liver Volume: 33 Suppl 1 ISSN: 1478-3231 ISO Abbreviation: Liver Int. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160857 Medline TA: Liver Int Country: United States |
Other Details:
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Languages: eng Pagination: 125-32 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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INSERM, U-773, CRB3, Université Paris-Diderot, Hôpital Beaujon, Clichy, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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