| The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG. | |
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MedLine Citation:
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PMID: 2877416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The developing epileptogenic electroencephalogram (EEG), seen during the slow intravenous infusion of leptazol, is sensitive to various anticonvulsant drugs, particularly those known to augment the function of gamma-aminobutyric acid (GABA), such as clonazepam and sodium valproate, which specifically prolong the earlier wave-like (pre-spiking) phases. Thus, whilst antagonism of GABA may be responsible for spiking, the early wave-like phases may be due to GABA released in the cortex as a feedback control to delay spiking. Intravenous infusion of the GABA antagonists, bicuculline and picrotoxin, produced a developing EEG with spiking the first abnormal feature noted and no wave-like phase, like that seen with leptazol. Cortical superfusion of GABA during the infusion of leptazol, enhanced kand prolonged the wave-like phase, whilst bicuculline reduced it. Cortical superfusion of leptazol, picrotoxin or larger concentrations of bicuculline produced spiking but no wave-like activity. When leptazol and GABA were superfused together they produced wave-like activity similar to that seen during infusions of leptazol. Of the excitatory amino acid antagonists, only those active at receptors for N-methyl-D-aspartate (NMDA) influenced the EEG changes induced by leptazol. It is suggested that leptazol produces waves in the EEG by stimulating subcortical pathways to release GABA in the cortex and that spiking occurs as the cortex is further stimulated by GABA antagonism and the release of excitatory amino acids. |
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Authors:
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A P Kent; R A Webster |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuropharmacology Volume: 25 ISSN: 0028-3908 ISO Abbreviation: Neuropharmacology Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-12-12 Completed Date: 1986-12-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1023-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allylglycine
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pharmacology Amino Acids / physiology* Animals Bicuculline / pharmacology Cerebral Cortex / drug effects Clonazepam / pharmacology Dose-Response Relationship, Drug Electroencephalography* GABA Antagonists Glutamates / pharmacology Glutamic Acid Male Pentylenetetrazole* Picrotoxin / pharmacology Rats Rats, Inbred Strains Seizures / chemically induced* Time Factors Valproic Acid / pharmacology gamma-Aminobutyric Acid / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/GABA Antagonists; 0/Glutamates; 1069-48-3/Allylglycine; 124-87-8/Picrotoxin; 1622-61-3/Clonazepam; 485-49-4/Bicuculline; 54-95-5/Pentylenetetrazole; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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