| The role of Fas mediated apoptosis in preeclampsia. | |
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MedLine Citation:
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PMID: 16318609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has become clear in recent years that apoptosis is a normal process in trophoblast turnover during pregnancy. Increased trophoblast apoptosis has been observed in the placenta of women with preeclampsia, serum from women with preeclampsia has been found to induce increased trophoblast sensitivity to Fas-mediated apoptosis, and serum from women with preeclampsia has elevated levels of various chemokines, growth factors and cytokines that are involved in the regulation of apoptosis. This review highlights the importance of apoptosis in normal placental development and explores the mechanisms whereby Fas-mediated apoptosis may play a role in conditions related to abnormal placentation, such as preeclampsia. |
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Authors:
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Donna M Neale; Gil Mor |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 33 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 2005 |
Date Detail:
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Created Date: 2005-12-01 Completed Date: 2006-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 471-7 Citation Subset: IM |
Affiliation:
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Department of Gynecology and Obstetrics, John Hopkins University School of Medicine, Baltimore, MD 21287, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD95 Apoptosis / physiology* Embryo Implantation / physiology Fas Ligand Protein Female Humans Membrane Glycoproteins / physiology Models, Biological Placenta / growth & development Pre-Eclampsia / etiology*, pathology, physiopathology Pregnancy Receptors, Tumor Necrosis Factor / physiology* Trophoblasts / immunology, pathology Tumor Necrosis Factors / physiology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/FAS protein, human; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Membrane Glycoproteins; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factors |
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