Document Detail

The role of Fas mediated apoptosis in preeclampsia.
MedLine Citation:
PMID:  16318609     Owner:  NLM     Status:  MEDLINE    
It has become clear in recent years that apoptosis is a normal process in trophoblast turnover during pregnancy. Increased trophoblast apoptosis has been observed in the placenta of women with preeclampsia, serum from women with preeclampsia has been found to induce increased trophoblast sensitivity to Fas-mediated apoptosis, and serum from women with preeclampsia has elevated levels of various chemokines, growth factors and cytokines that are involved in the regulation of apoptosis. This review highlights the importance of apoptosis in normal placental development and explores the mechanisms whereby Fas-mediated apoptosis may play a role in conditions related to abnormal placentation, such as preeclampsia.
Donna M Neale; Gil Mor
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  33     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-01     Completed Date:  2006-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  471-7     Citation Subset:  IM    
Department of Gynecology and Obstetrics, John Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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MeSH Terms
Antigens, CD95
Apoptosis / physiology*
Embryo Implantation / physiology
Fas Ligand Protein
Membrane Glycoproteins / physiology
Models, Biological
Placenta / growth & development
Pre-Eclampsia / etiology*,  pathology,  physiopathology
Receptors, Tumor Necrosis Factor / physiology*
Trophoblasts / immunology,  pathology
Tumor Necrosis Factors / physiology
Reg. No./Substance:
0/Antigens, CD95; 0/FAS protein, human; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Membrane Glycoproteins; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factors

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