| The role of FDG PET/CT in patients with locoregional breast cancer recurrence: a comparison to conventional imaging techniques. | |
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MedLine Citation:
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PMID: 19962268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to evaluate the impact of (18)F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) on clinical management in patients with locoregional breast cancer recurrence amenable for locoregional treatment and to compare the PET/CT results with the conventional imaging data. PATIENTS AND METHODS: From January 2006 to August 2008, all patients with locoregional breast cancer recurrence underwent whole-body PET/CT. PET/CT findings were compared with results of the conventional imaging techniques and final pathology. The impact of PET/CT results on clinical management was evaluated based on clinical decisions obtained from patient files. RESULTS: 56 patients were included. In 32 patients (57%) PET/CT revealed additional tumour localisations. Distant metastases were detected in 11 patients on conventional imaging and in 23 patients on PET/CT images (p < 0.01). In 25 patients (45%), PET/CT detected additional lesions not visible on conventional imaging. PET/CT had an impact on clinical management in 27 patients (48%) by detecting more extensive locoregional disease or distant metastases. In 20 patients (36%) extensive surgery was prevented and treatment was changed to palliative treatment. The sensitivity, specificity, accuracy, positive and negative predictive values of FDG PET/CT were respectively 97%, 92%, 95%, 94% and 96%. CONCLUSIONS: PET/CT, in addition to conventional imaging techniques, plays an important role in staging patients with locoregional breast cancer recurrence since its result changed the clinical management in almost half of the patients. PET/CT could potentially replace conventional staging imaging in patients with a locoregional breast cancer recurrence. |
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Authors:
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T S Aukema; E J Th Rutgers; W V Vogel; H J Teertstra; H S Oldenburg; M T F D Vrancken Peeters; J Wesseling; N S Russell; R A Vald?s Olmos |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-12-03 |
Journal Detail:
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Title: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Volume: 36 ISSN: 1532-2157 ISO Abbreviation: Eur J Surg Oncol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-16 Completed Date: 2010-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504356 Medline TA: Eur J Surg Oncol Country: England |
Other Details:
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Languages: eng Pagination: 387-92 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Nuclear Medicine, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. t.aukema@nki.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Breast Neoplasms / pathology, radiography*, radionuclide imaging* Chi-Square Distribution Female Fluorodeoxyglucose F18 / diagnostic use* Humans Image Interpretation, Computer-Assisted Middle Aged Neoplasm Recurrence, Local / pathology, radiography*, radionuclide imaging* Predictive Value of Tests Radiopharmaceuticals / diagnostic use* Sensitivity and Specificity Tomography, Emission-Computed / methods* Tomography, X-Ray Computed / methods* Whole Body Imaging |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
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