| The role of FDG PET-CT in differential diagnosis of pleural pathologies. | |
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MedLine Citation:
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PMID: 21944189 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: This study has aimed to evaluate the impact of (F18) Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG PET-CT) in the differential diagnosis of malignant and benign pleural lesions in patients with suspected malignant pleural mesothelioma (MPM). MATERIAL AND METHODS: Fifty patients (32 females, 18 males; age range 24-79 years) with pleural thickening, fluid, plaques or calcification on previous CT scan were examined with FDG PET-CT. PET-CT imaging was obtained 1h after FDG injection. In 12 patients, delayed imaging from the thoracic region was performed 2h after injection. FDG uptake was evaluated visually and semiquantitively using standardized uptake value (SUV). FDG PET-CT findings were compared with histopathologic diagnosis. RESULTS: Thirty-nine patients had increased FDG uptake in pleural lesions but PET-CT results were negative in 11 patients. When compared with histopathological results in FDG positive group, 34 patients had MPM, 5 had benign pathology; in FDG negative group 8 patients had benign pathology, 3 had MPM. Of patients with delayed imaging, 9 showed increased SUV but 3 had a decreased SUV on delayed images. Increased SUV group had 4 MPM, 5 benign pathology (3 chronic granulomatous inflammation, 2 benign asbestotic plaque). Decreased SUV group all had benign pathology (fibrosis, chronic inflammation, myofibrosis). DISCUSSION: FDG PET-CT is a useful imaging modality in differential diagnosis of malignant and benign pleural lesions. Delayed imaging seems to be useful if there is a decrease in SUV suggesting a benign pathology but does not seem to contribute to the differential diagnosis if the SUV is increased. |
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Authors:
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U Elboga; M Yılmaz; M Uyar; Y Zeki Çelen; K Bakır; O Dikensoy |
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Publication Detail:
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Type: - Date: 2011-9-21 |
Journal Detail:
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Title: Revista espanola de medicina nuclear Volume: - ISSN: 0212-6982 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208726 Medline TA: Rev Esp Med Nucl Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier España, S.L. and SEMNIM. All rights reserved. |
Affiliation:
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Department of Nuclear Medicine, University of Gaziantep, School of Medicine, Gaziantep, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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