Document Detail

The role of Escherichia coli O 157 infections in the classical (enteropathic) haemolytic uraemic syndrome: results of a Central European, multicentre study.
MedLine Citation:
PMID:  8472763     Owner:  NLM     Status:  MEDLINE    
To assess the importance of infection by Verotoxin (VT) producing Escherichia coli (VTEC) in children with HUS in Central Europe, stool and/or serum samples obtained from 147 patients from 28 paediatric centres were prospectively examined for the presence of VTEC and the kinetics of faecal VT titres (FVT), and for VT neutralization titres and antibodies against E. coli O 157 lipopolysaccharide, respectively. Ninety-two percent of the patients had classic (enteropathic) HUS (E+ HUS). Evidence of VTEC infection was obtained in 86% of them. VTEC/FVT were identified in 55/118 E+ cases (47%). A prominent feature was the frequent isolation of sorbitol-fermenting, VT2-producing E. coli O 157.H-.VT1 (C600/H19) was neutralized by 9%, and VT2 (C600/933W) by 99% of the initial serum samples from E+ patients, compared to 3% (VT1) and 100% (VT2) from age-related controls. Fourfold titre rises against VT1 and/or VT2 were observed in 13/70 (19%), and significantly elevated O 157 LPS IgM and/or IgA antibodies in 106/128 (83%) of the E+ patients. The ubiquitous VT2 neutralizing principle in the serum of HUS patients as of healthy controls warrants further investigations.
M Bitzan; K Ludwig; M Klemt; H König; J Büren; D E Müller-Wiefel
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Epidemiology and infection     Volume:  110     ISSN:  0950-2688     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-18     Completed Date:  1993-05-18     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  183-96     Citation Subset:  IM    
Kinderklinik, Universitätskrankenhaus Hamburg-Eppendorf, Federal Republic of Germany.
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MeSH Terms
Antibodies, Bacterial / analysis
Bacterial Toxins / biosynthesis*,  immunology
Child, Preschool
Cytotoxins / biosynthesis,  immunology
Enterotoxins / biosynthesis,  immunology
Escherichia coli / immunology,  isolation & purification,  metabolism*
Escherichia coli Infections / diagnosis*
Feces / microbiology
Hemolytic-Uremic Syndrome / microbiology*
Immunoglobulins / analysis
Lipopolysaccharides / analysis
Prospective Studies
Shiga Toxin 1
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Toxins; 0/Cytotoxins; 0/Enterotoxins; 0/Immunoglobulins; 0/Lipopolysaccharides; 0/Shiga Toxin 1

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