Document Detail


The role of CRH receptors and their agonists in myometrial contractility and quiescence during pregnancy and labour.
MedLine Citation:
PMID:  17127317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism of human labor remains a scientific enigma. Corticotropin-releasing hormone (CRH), a hypothalamic peptide that controls the response of the body to stress and which is also produced by the placenta and intrauterine tissues during pregnancy is potentially involved in the onset of labor. CRH is part of a family of mammalian peptides that includes the urocortins (UCNs), which are also expressed by the placenta and intrauterine tissues. During human pregnancy, CRH appears to target multiple feto-maternal tissues, including the myometrium, implicating CRH in the regulation of the transition from relaxation to active uterine contractions. The myometrial actions of CRH are mediated via a wide network of specific G-protein coupled membrane-bound receptors. These receptors have various functional properties, depending on the receptor subtype, the ability of agonists to activate specific signalling cascades and the stage of pregnancy. In addition, their function is dependent upon other intracellular signals via communication between signalling cascades, suggesting potential multiple roles of CRH and other CRH-like peptides during pregnancy and labor. This review will provide the current concepts about the role of CRH and UCNs and their myometrial receptors during pregnancy, labor and delivery.
Authors:
Dimitris K Grammatopoulos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-01-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  12     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2007  
Date Detail:
Created Date:  2006-11-27     Completed Date:  2007-08-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  561-71     Citation Subset:  IM    
Affiliation:
Endocrinology and Metabolism, Division of Clinical Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom. d.grammatopoulos@warwick.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Corticotropin-Releasing Hormone / physiology
Female
Humans
Labor, Obstetric / physiology*
Myometrium / physiology*
Pregnancy
Receptors, Corticotropin-Releasing Hormone / agonists,  physiology*
Urocortins
Uterine Contraction*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Receptors, Corticotropin-Releasing Hormone; 0/Urocortins; 9015-71-8/Corticotropin-Releasing Hormone

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