Document Detail

The role of CRF in behavioral aspects of stress.
MedLine Citation:
PMID:  8597448     Owner:  NLM     Status:  MEDLINE    
CRF in the central nervous system appears to hve activating properties on behavior and to coordinate behavioral responses to stressors. These behavioral effects of CRF appear to be independent of the pituitary-adrenal axis and can be reversed by CRF antagonists. CRF antagonist administration reverses not only decreases in behavior associated with stress, but also increases in behavior associated with stress, thus suggesting that the role of CRF is stress dependent and not intrinsic to a given behavioral response. Further, microinjection of alpha-helical CRF 9-41 and immunotargeting of CRF neurons in separate brain compartments reveal a link between the anatomical sites that contain CRF and the nature of the behavioral response to stressors that can be modified by suppression of endogenous CRF activity therein. These actions of CRF in coordinating coping responses to stress at several bodily levels are consistent with a role for CRF similar to the dual role of other hypothalamic releasing factors in integrating hormonal and neural mechanisms by acting both as secretagogues for anterior pituitary hormones and as extrapituitary peptide neurotransmitters. Moreover, dysfunction in such a fundamental homeostatic system may be the key to a variety of pathophysiological conditions including mental disorders.
S C Heinrichs; F Menzaghi; E Merlo Pich; K T Britton; G F Koob
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  771     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-04-17     Completed Date:  1996-04-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  92-104     Citation Subset:  IM    
Scripps Research Institute, Department of Neuropharmacology CVN7, La Jolla, California 92037, USA.
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MeSH Terms
Amygdala / physiology
Behavior, Animal / physiology*
Brain / physiology*
Corticotropin-Releasing Hormone / antagonists & inhibitors,  physiology*
Paraventricular Hypothalamic Nucleus / physiology
Stress, Physiological / physiopathology*
Reg. No./Substance:
9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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