Document Detail


The role of CK7, Ki-67, CD34 and vimentin in the differentiation between biliary atresia and idiopathic neonatal hepatitis in Egyptian cholestatic neonates.
MedLine Citation:
PMID:  22716208     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aiad HAS, Kandil MAH, Samaka RM, Sultan MM, Badr MT, Nada GEM. The role of ck7, ki-67, cd34 and vimentin in the differentiation between biliary atresia and idiopathic neonatal hepatitis in egyptian cholestatic neonates. APMIS 2012; 120: 529-38. The differentiation between biliary atresia (BA) and idiopathic neonatal hepatitis (INH) is challenging with many histological overlaps especially in the first weeks of life. This study aimed to investigate the role of immunohistochemical staining of CK7, Ki67, CD34, and vimentin in addition to other clinicopathological features in the differentiation between BA and INH. Cases included 30 infants with BA and 30 infants with INH. The diagnosis was based on clinical, laboratory, and liver biopsy examination. Female gender and elevated serum gamma glutamyle transferase were in favor of BA. Portal tract changes, such as bile ductular proliferation documented by CK7, Ki67 immunostaining and angiogenesis documented by CD34 immunostaining, favored the diagnosis of BA. Copper associated protein was positive in 70% of BA cases, but not detected in INH cases. Parenchymatous changes, such as giant cell transformation and positive iron deposition and Kupffer cell proliferation documented by vimentin immunostaining, favored the diagnosis of INH.CK7, Ki67, CD34, and vimentin are helpful adjuvant immunostaining in the differentiation between BA and INH.
Authors:
Hayam Abdel Samie Aiad; Mona Abdel Halim Kandil; Rehab Monir Samaka; Mervat Mahmoud Sultan; Mohamed Tawfik Badr; Gammal Eldin Mahmoud Nada
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Publication Detail:
Type:  Journal Article     Date:  2012-01-12
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  120     ISSN:  1600-0463     ISO Abbreviation:  APMIS     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  529-38     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. APMIS © 2012 APMIS.
Affiliation:
Department of Pathology, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt Department of Pathology, National Liver Institute, Menoufiya University, Menoufiya, Egypt Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
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