Document Detail

A role for CD81 in early T cell development.
MedLine Citation:
PMID:  8539618     Owner:  NLM     Status:  MEDLINE    
Early stages of T cell development are thought to include a series of coordinated interactions between thymocytes and other cells of the thymus. A monoclonal antibody specific for mouse CD81 was identified that blocked the appearance of alpha beta but not gamma delta T cells in fetal organ cultures initiated with day 14.5 thymus lobes. In reaggregation cultures with CD81-transfected fibroblasts, CD4-CD8- thymocytes differentiated into CD4+CD8+ T cells. Thus, interactions between immature thymocytes and stromal cells expressing CD81 are required and may be sufficient to induce early events associated with T cell development.
R Boismenu; M Rhein; W H Fischer; W L Havran
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  271     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-08     Completed Date:  1996-02-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  198-200     Citation Subset:  IM    
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.
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MeSH Terms
Amino Acid Sequence
Antibodies, Monoclonal / immunology
Antigens, CD / genetics,  immunology,  physiology*
Antigens, CD4 / analysis
Antigens, CD8 / analysis
Base Sequence
CHO Cells
Cell Differentiation
Membrane Proteins / immunology,  physiology*
Molecular Sequence Data
Organ Culture Techniques
Receptors, Antigen, T-Cell, alpha-beta / analysis*
Receptors, Antigen, T-Cell, gamma-delta / analysis
Stromal Cells / immunology
T-Lymphocyte Subsets / cytology,  immunology*
Thymus Gland / cytology,  immunology*
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD; 0/Antigens, CD4; 0/Antigens, CD8; 0/CD81 antigen; 0/Membrane Proteins; 0/Receptors, Antigen, T-Cell, alpha-beta; 0/Receptors, Antigen, T-Cell, gamma-delta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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