Document Detail

The role of CD8+ T cell soluble factors in human immunodeficiency virus infection.
MedLine Citation:
PMID:  12369877     Owner:  NLM     Status:  MEDLINE    
Cell-mediated immune responses are important for the control of HIV replication in vivo. Cytotoxic CD8+ T cells (CTL) recognize and kill HIV-infected cells which display MHC class-I proteins. In addition to the recognition and killing of infected cells, CD8+T cells can interfere with stages of the HIV life-cycle. Chemokines produced by CD8+ T cells bind to their seven-transmembrane G protein-coupled receptors resulting in a block in the entry of HIV into macrophages and T cells. In addition, activated CD8+ T cells produce factors which strongly modulate HIV at the level of transcription. This review will focus primarily on the current knowledge of the multifactorial functions of CD8+ T cells in HIV infection. An understanding of the mechanisms involved in the CD8-mediated control of transcription may identify other factors with potential value in the treatment of HIV infection.
K F T Copeland
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  9     ISSN:  0929-8673     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-08     Completed Date:  2003-03-13     Revised Date:  2007-02-12    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1781-90     Citation Subset:  IM    
Centre for Molecular Medicine, Ottawa Health Research Institute, Ottawa, Ontario, Canada.
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MeSH Terms
Antiviral Agents / immunology
CD8-Positive T-Lymphocytes / immunology*
Chemokines / immunology
HIV Infections / immunology*
Reg. No./Substance:
0/Antiviral Agents; 0/Chemokines

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