Document Detail


The role of CD5-expressing B cells in health and disease (review).
MedLine Citation:
PMID:  10028047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The CD5(+) B cell population is prominent in early life and produce low avidity and, thereby, polyreactive antibodies. CD5(+) B cells are receptive to cytokines and interleukin-10 seems to be influential in the regulation of some of these CD5(+) B cells. The question of whether CD5 is a marker of activation or a molecule specific for a B cell lineage remains unresolved because evidence in support or against a separate lineage are still a matter for debate. However, we suggest the possibility of different kind of CD5(+) B cells. Indeed, activated CD5(+) B cells do proliferate, following CD5 engagement, while resting CD5(+) B cells do not. Moreover, three ligands for CD5 have, thus far, been identified but their functional effects are yet unknown. CD5(+) B cells probably play a role in setting up the idiotype network, antigen presentation and tolerance induction. B cells of most of the chronic lymphoid leukemias express CD5 molecules and, surprisingly, these cells may be expanded in non-organ-specific autoimmune diseases, such as rheumatoid arthritis or primary Sjögren's syndrome. CD5(+) B cells seems to be involved in the autoantibody production (this does not necessarily imply that pathogenic autoantibodies are produced by CD5(+) B cells) in autoimmune disease and particularly susceptible to transformation in lymphoproliferative disorders. Thus, this B cell population appears to play a key role at the crossroad of the non-organ-specific autoimmune diseases and B lymphoproliferative disorders.
Authors:
J O Pers; C Jamin; F Predine-Hug; P Lydyard; P Youinou
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  3     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  2000-10-13     Completed Date:  2000-10-13     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  239-45     Citation Subset:  IM    
Affiliation:
Division of Dentistry, Brest University Medical School Hospital, Brest, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD5 / immunology*
Arthritis, Rheumatoid / immunology
Autoimmunity / immunology*
B-Lymphocytes / immunology*,  metabolism*
Cell Lineage
Health
Humans
Leukemia / immunology
Lupus Erythematosus, Systemic / immunology
Lymphocyte Activation
Lymphoma / immunology
Chemical
Reg. No./Substance:
0/Antigens, CD5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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