| The role of BNP testing in heart failure. | |
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MedLine Citation:
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PMID: 17168346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Brain natriuretic peptide (BNP) levels are simple and objective measures of cardiac function. These measurements can be used to diagnose heart failure, including diastolic dysfunction, and using them has been shown to save money in the emergency department setting. The high negative predictive value of BNP tests is particularly helpful for ruling out heart failure. Treatment with angiotensin-converting enzyme inhibitors, angiotensin-II receptor blockers, spironolactone, and diuretics reduces BNP levels, suggesting that BNP testing may have a role in monitoring patients with heart failure. However, patients with treated chronic stable heart failure may have levels in the normal range (i.e., BNP less than 100 pg per mL and N-terminal proBNP less than 125 pg per mL in patients younger than 75 years). Increases in BNP levels may be caused by intrinsic cardiac dysfunction or may be secondary to other causes such as pulmonary or renal diseases (e.g., chronic hypoxia). BNP tests are correlated with other measures of cardiac status such as New York Heart Association classification. BNP level is a strong predictor of risk of death and cardiovascular events in patients previously diagnosed with heart failure or cardiac dysfunction. |
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Authors:
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Jenny Doust; Richard Lehman; Paul Glasziou |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American family physician Volume: 74 ISSN: 0002-838X ISO Abbreviation: Am Fam Physician Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-15 Completed Date: 2007-01-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1272646 Medline TA: Am Fam Physician Country: United States |
Other Details:
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Languages: eng Pagination: 1893-8 Citation Subset: AIM; IM |
Affiliation:
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University of Queensland, Brisbane, Australia. j.doust@sph.uq.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Heart Failure / blood, diagnosis*, mortality Humans Natriuretic Peptide, Brain / blood*, drug effects |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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