Document Detail


A role for B lymphocytes in anti-infective prion therapies?
MedLine Citation:
PMID:  17678426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic feature of a number of neurodegenerative conditions affecting the nervous system. These disorders include prion and Alzheimer's diseases and are of enormous importance for public health. It has become apparent over the last 20 years that specificity and application in prion diseases' diagnostic and therapeutic situations are the most important considerations in designing strategies for the generation of antiprion antibodies. Specific antiprion therapeutics have been suggested and the establishment of the 'proof-of-principle' that the use of epitope-specific antiprion antibodies leads to indefinite delay of disease onset, has increased momentum for its use, although caution should be exerted prior to the application of new therapeutic strategies in a clinical set up. Furthermore, in vivo stimulation of immune-competent cells to specifically recognize and neutralize the abnormally folded isoform should also be pursued.
Authors:
Mourad Tayebi; Clive Bate; Simon Hawke; Alun Williams
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of anti-infective therapy     Volume:  5     ISSN:  1744-8336     ISO Abbreviation:  Expert Rev Anti Infect Ther     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-06     Completed Date:  2007-09-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181284     Medline TA:  Expert Rev Anti Infect Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  631-8     Citation Subset:  IM    
Affiliation:
Department of Pathology and Infectious Diseases, The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire, UK. mtayebi@rvc.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies / therapeutic use
B-Lymphocytes / immunology*
Humans
PrPSc Proteins / immunology
Prion Diseases / immunology,  therapy*
Chemical
Reg. No./Substance:
0/Antibodies; 0/PrPSc Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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