| The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 19411764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE. |
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Authors:
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Michael P Cancro; David P D'Cruz; Munther A Khamashta |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-05-01 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 119 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-04 Completed Date: 2009-06-08 Revised Date: 2010-09-24 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 1066-73 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104-6082, USA. cancro@mail.med.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoantibodies / immunology B-Cell Activating Factor / physiology* B-Lymphocytes / cytology, physiology Clinical Trials as Topic Humans Lupus Erythematosus, Systemic / immunology, metabolism*, therapy Models, Biological Self Tolerance / physiology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/B-Cell Activating Factor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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