Document Detail


The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus.
MedLine Citation:
PMID:  19411764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE.
Authors:
Michael P Cancro; David P D'Cruz; Munther A Khamashta
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-05-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  119     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-06-08     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1066-73     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104-6082, USA. cancro@mail.med.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoantibodies / immunology
B-Cell Activating Factor / physiology*
B-Lymphocytes / cytology,  physiology
Clinical Trials as Topic
Humans
Lupus Erythematosus, Systemic / immunology,  metabolism*,  therapy
Models, Biological
Self Tolerance / physiology
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/B-Cell Activating Factor
Comments/Corrections

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