| The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat. | |
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MedLine Citation:
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PMID: 20303940 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the role of K(ATP) channel on acute urinary retention (AUR) induced bladder dysfunction. Eight-week-old female Sprague-Dawley rats were divided into seven groups: a sham-operated control group, an AUR group, and five AUR groups treated with: two different K(ATP) channel openers namely nicorandil (3 or 10mg/kg), or cromakalim (100 or 300microg/kg), or one K(ATP) channel inhibitor namely glibenclamide (5mg/kg). The drugs were administered 30min before induction of AUR. After the urethra was obstructed with a clip, AUR was induced by intravesical infusion of 2.5ml of saline via cystostomy. Following a 30min obstruction the bladder was allowed to drain with a catheter in place for 60min with real-time monitoring of intravesical pressure and blood flow. After the experimental period, the bladder function was assessed, using organ bath techniques (carbachol and 100mM KCl). AUR increased the intravesical pressure and decreased the blood flow. The subsequent catheterization decreased the intravesical pressure and increased the blood flow. AUR group reduced significantly the contractile responses to both carbachol and KCl compared with the control group. Nicorandil and cromakalim but not glibenclamide prevented the bladder dysfunction after AUR suggesting that K(ATP) channel openers may prevent the bladder dysfunction caused by AUR and subsequent catheterization. |
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Authors:
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Fumiya Ohmasa; Motoaki Saito; Shogo Shimizu; Sousuke Taniguchi; Fotios Dimitriadis; Itaru Satoh; Yukako Kinoshita; Keisuke Satoh |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-19 |
Journal Detail:
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Title: European journal of pharmacology Volume: 635 ISSN: 1879-0712 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 194-7 Citation Subset: IM |
Affiliation:
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Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Tottori University School of Medicine, Nishi-machi, Yonago, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Circulation / drug effects Blood Pressure / drug effects Cromakalim / pharmacology Dose-Response Relationship, Drug Female Glyburide / pharmacology Ion Channel Gating / drug effects KATP Channels / antagonists & inhibitors, metabolism* Muscle Contraction / drug effects Nicorandil / pharmacology Potassium Channel Blockers / pharmacology Potassium Chloride / pharmacology Rats Rats, Sprague-Dawley Urinary Bladder / blood supply, drug effects, metabolism, physiopathology Urinary Catheterization* Urinary Retention / metabolism*, physiopathology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/KATP Channels; 0/Potassium Channel Blockers; 10238-21-8/Glyburide; 65141-46-0/Nicorandil; 7447-40-7/Potassium Chloride; 94470-67-4/Cromakalim |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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