Document Detail

The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat.
MedLine Citation:
PMID:  20303940     Owner:  NLM     Status:  MEDLINE    
We investigated the role of K(ATP) channel on acute urinary retention (AUR) induced bladder dysfunction. Eight-week-old female Sprague-Dawley rats were divided into seven groups: a sham-operated control group, an AUR group, and five AUR groups treated with: two different K(ATP) channel openers namely nicorandil (3 or 10mg/kg), or cromakalim (100 or 300microg/kg), or one K(ATP) channel inhibitor namely glibenclamide (5mg/kg). The drugs were administered 30min before induction of AUR. After the urethra was obstructed with a clip, AUR was induced by intravesical infusion of 2.5ml of saline via cystostomy. Following a 30min obstruction the bladder was allowed to drain with a catheter in place for 60min with real-time monitoring of intravesical pressure and blood flow. After the experimental period, the bladder function was assessed, using organ bath techniques (carbachol and 100mM KCl). AUR increased the intravesical pressure and decreased the blood flow. The subsequent catheterization decreased the intravesical pressure and increased the blood flow. AUR group reduced significantly the contractile responses to both carbachol and KCl compared with the control group. Nicorandil and cromakalim but not glibenclamide prevented the bladder dysfunction after AUR suggesting that K(ATP) channel openers may prevent the bladder dysfunction caused by AUR and subsequent catheterization.
Fumiya Ohmasa; Motoaki Saito; Shogo Shimizu; Sousuke Taniguchi; Fotios Dimitriadis; Itaru Satoh; Yukako Kinoshita; Keisuke Satoh
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-19
Journal Detail:
Title:  European journal of pharmacology     Volume:  635     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  194-7     Citation Subset:  IM    
Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Tottori University School of Medicine, Nishi-machi, Yonago, Japan.
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MeSH Terms
Blood Circulation / drug effects
Blood Pressure / drug effects
Cromakalim / pharmacology
Dose-Response Relationship, Drug
Glyburide / pharmacology
Ion Channel Gating / drug effects
KATP Channels / antagonists & inhibitors,  metabolism*
Muscle Contraction / drug effects
Nicorandil / pharmacology
Potassium Channel Blockers / pharmacology
Potassium Chloride / pharmacology
Rats, Sprague-Dawley
Urinary Bladder / blood supply,  drug effects,  metabolism,  physiopathology
Urinary Catheterization*
Urinary Retention / metabolism*,  physiopathology,  therapy*
Reg. No./Substance:
0/KATP Channels; 0/Potassium Channel Blockers; 10238-21-8/Glyburide; 65141-46-0/Nicorandil; 7447-40-7/Potassium Chloride; 94470-67-4/Cromakalim

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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