Document Detail


A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes.
MedLine Citation:
PMID:  1577105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurons in the region of the rostral nucleus paragigantocellularis (nPGi) mediate the inhibition of spinal sexual reflexes. Anatomical and pharmacological evidence is presented supporting a role for 5-hydroxytryptamine (5-HT) in this inhibition. Neurons in the rostral nPGi project to the ventral horn in the vicinity of the pudendal motoneurons. A significant number (78% ipsilateral) of these neurons contain 5-HT. Anterograde tracing with Phaseolus leucoagglutinin (PHA-L) confirmed the nPGi projection to pudendal motoneuron and interneuronal areas of the lumbar cord. 5-HT immunoreactive fibers and presumptive terminals surround the pudendal motoneurons. Urethral stimulation, in the anesthetized male rat, elicited penile erections, ejaculation and rhythmic contractions of the perineal muscles, we have used the term coitus reflex to describe this response. Intrathecal injection of 5-HT (4-50 micrograms) abolished the coitus reflex. Methysergide (1-10 mg/kg i.v.) prevented the 5-HT induced blockade of the coitus reflex. These data support the hypothesis that 5-HT is involved in the descending inhibition of spinal sexual reflexes.
Authors:
L Marson; K E McKenna
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental brain research     Volume:  88     ISSN:  0014-4819     ISO Abbreviation:  Exp Brain Res     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-08     Completed Date:  1992-06-08     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Copulation / physiology
Ejaculation / physiology
Electromyography
Immunohistochemistry
Male
Medulla Oblongata / cytology,  physiology
Motor Neurons / physiology
Penile Erection / physiology
Phytohemagglutinins
Rats
Rats, Inbred Strains
Reflex / physiology*
Serotonin / physiology*
Sexual Behavior, Animal / physiology*
Spinal Cord / cytology,  physiology*
Grant Support
ID/Acronym/Agency:
NS 26157/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Phytohemagglutinins; 0/leukoagglutinins, plants; 333DO1RDJY/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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