Document Detail

The role of 20-HETE in androgen-mediated hypertension.
MedLine Citation:
PMID:  21722750     Owner:  NLM     Status:  MEDLINE    
Androgen plays an important role in blood pressure regulation. Epidemiological studies have shown that men have a higher prevalence for developing hypertension than aged-matched, premenopausal women. Interestingly, postmenopausal women and women with polycystic ovary syndrome, both of which have increased endogenous androgen production, have elevated risks for hypertension suggesting that androgen may contribute to its development. Studies from our laboratory and others have provided substantial evidence that 20-hydroxyeicosatetraenoic acid (20-HETE) mediates the hypertension seen in rodents treated with androgen. 20-HETE is the cytochrome P450 (CYP)-derived ω-hydroxylated metabolite of arachidonic acid. 20-HETE plays a complex role in blood pressure regulation. In the kidney tubules, 20-HETE decreases blood pressure by promoting natriuresis, while in the microvasculature it has a pressor effect. In the microcirculation, 20-HETE participates in the regulation of vascular tone by sensitizing the smooth muscle cells to constrictor stimuli and contributes to myogenic, mitogenic and angiogenic responses. In addition, 20-HETE acts on the endothelium to promote endothelial dysfunction and endothelial activation. Recently, we have demonstrated that 20-HETE induces endothelial ACE thus setting forth a potential feed forward mechanism through activation of the renin-angiotensin-aldosterone system. In this review, we will discuss the pro-hypertensive effects of 20-HETE and its role in androgen-induced vascular dysfunction and hypertension.
Cheng-Chia Wu; Michal Laniado Schwartzman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-06-22
Journal Detail:
Title:  Prostaglandins & other lipid mediators     Volume:  96     ISSN:  1098-8823     ISO Abbreviation:  Prostaglandins Other Lipid Mediat.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-14     Completed Date:  2012-04-17     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9808648     Medline TA:  Prostaglandins Other Lipid Mediat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Acetylcholinesterase / genetics,  metabolism
Alkane 1-Monooxygenase / metabolism
Androgens / adverse effects,  metabolism*,  pharmacology
Arachidonic Acid / metabolism*
Blood Pressure* / drug effects
Endothelial Cells / metabolism*
Enzyme Induction / drug effects
Hydroxyeicosatetraenoic Acids / metabolism*
Hypertension / metabolism*,  physiopathology
Kidney / metabolism,  physiopathology
Natriuresis / drug effects
Renin-Angiotensin System / physiology
Signal Transduction* / drug effects
Grant Support
F30 HL097402/HL/NHLBI NIH HHS; F30 HL097402/HL/NHLBI NIH HHS; F30 HL097402-01/HL/NHLBI NIH HHS; F30 HL097402-02/HL/NHLBI NIH HHS; F30 HL097402-03/HL/NHLBI NIH HHS; F30 HL097402-04/HL/NHLBI NIH HHS; HL034300/HL/NHLBI NIH HHS; P01 HL034300/HL/NHLBI NIH HHS; P01 HL034300-25/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Androgens; 0/Hydroxyeicosatetraenoic Acids; 27YG812J1I/Arachidonic Acid; 79551-86-3/20-hydroxy-5,8,11,14-eicosatetraenoic acid; EC 1-Monooxygenase; EC

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