| The role of 18F-FDG PET/CT in detecting metastatic deposits of recurrent medullary thyroid carcinoma: a prospective study. | |
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MedLine Citation:
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PMID: 17892923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To assess the diagnostic role of 18F-FDG PET/CT performed with a hybrid tomograph in the detection of tumoral deposits of recurrent medullary thyroid carcinoma (MTC). METHODS: Nineteen MTC patients with elevated serum calcitonin levels (58-1350 pg/ml) after first treatment were enrolled (11 F, 8 M, mean age 53.4 years, 14 sporadic MTC, 5 MEN-related MTC). All patients had previously undergone total thyroidectomy and lymphoadenectomy. When referred to us, they were studied with ultrasound (US), 18F-FDG PET/CT, (111)In-pentetreotide scan, and contrast-enhanced whole-body CT (c.e. CT). In 4 patients with equivocal abdominal findings at 18F-FDG PET/CT and/or at c.e. CT, laparoscopy was also performed. RESULTS: 18F-FGD PET/CT depicted metastases in 15 patients, 111In-pentetreotide in 8, c.e. CT in 11, US in 6. In 2 patients, liver micrometastases were detected at laparoscopy only. At a lesion-by-lesion analysis, 18F-FDG PET/CT visualized a total of 26 metastatic deposits, c.e. CT 18, 111In-pentetreotide 12, US 8. Final diagnosis was obtained by cytological or surgical findings. Four patients with evidence of limited metastatic spread to neck/upper mediastinum were re-operated, and in 2 of them serum calcitonin levels normalized. CONCLUSIONS: In our study, 18F-FDG PET/CT was the most sensitive imaging modality in detecting metastases in recurrent MTC patients with increased serum calcitonin levels. Moreover, 18F-FDG PET/CT was useful in some patients to plan a more accurate re-operation. From a diagnostic point of view, a multimodality imaging approach is recommended in recurrent MTC, especially based on the combination of c.e. CT and 18F-FDG PET/CT. |
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Authors:
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D Rubello; L Rampin; C Nanni; E Banti; M Ferdeghini; S Fanti; A Al-Nahhas; M D Gross |
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Publication Detail:
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Type: Journal Article Date: 2007-09-24 |
Journal Detail:
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Title: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Volume: 34 ISSN: 1532-2157 ISO Abbreviation: Eur J Surg Oncol Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-21 Completed Date: 2008-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504356 Medline TA: Eur J Surg Oncol Country: England |
Other Details:
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Languages: eng Pagination: 581-6 Citation Subset: IM |
Affiliation:
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Nuclear Medicine Service, S. Maria della Misericordia Rovigo Hospital, Istituto Oncologico Veneto (IOV)-IRCCS, Rovigo, Italy. domenico.rubello@libero.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcitonin
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blood Carcinoma, Medullary / radionuclide imaging*, secondary Female Fluorodeoxyglucose F18 / diagnostic use Humans Male Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local / radionuclide imaging* Positron-Emission Tomography* Prospective Studies Thyroid Neoplasms / pathology, radionuclide imaging* Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18; 9007-12-9/Calcitonin |
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