| The role of [(18) F]-2-fluoro-2-deoxy-d-glucose-positron emission tomography in thyroid nodules with indeterminate fine-needle aspiration biopsy: Systematic review and meta-analysis of the literature. | |
| | |
MedLine Citation:
|
PMID: 21432844 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Indeterminate results at fine-needle aspiration biopsy (FNAB) of thyroid nodules pose a clinical dilemma, because only 20% to 30% of patients suffer from malignancy. Previous studies suggested that the false-negative ratio of [(18) F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) is very low; therefore, it may help identify patients who would benefit from (hemi)thyroidectomy. A systematic literature search was performed in 5 databases. After assessment, the identified studies were analyzed for heterogeneity, and the extracted data of test characteristics were pooled using a random-effects model. Threshold effects were examined, and publication bias was assessed. The query resulted in 239 records, of which 6 studies met predefined inclusion criteria. Data from 225 of the 241 described patients could be extracted. There was mild to moderate heterogeneity in study results (inconsistency index [I(2) ] = 0.390-0.867). The pooled prevalence of malignancy was 26%. Pooled sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 95% (95% confidence interval [95% CI], 86%-99%), 48% (95% CI, 40%-56%), 39% (95% CI, 31%-47%), 96% (95% CI, 90%-99%), and 60% (95% CI, 53%-67%), respectively. Sensitivity increased to 100% for the 164 lesions that measured >15 mm in greatest dimension. There was no evidence of threshold effects or publication bias. A negative FDG-PET scan in patients who had thyroid nodules >15 mm with indeterminate FNAB results excluded thyroid cancer in a pooled population of 225 patients. Conversely, a positive FDG-PET result did not identify cancer, because approximately 50% of these patients had benign nodules. The authors concluded that the incorporation of FDG-PET into the initial workup of such patients before surgery deserves further investigation. Cancer 2011. © 2011 American Cancer Society. |
| | |
Authors:
|
Dennis Vriens; Johannes H W de Wilt; Gert J van der Wilt; Romana T Netea-Maier; Wim J G Oyen; Lioe Fee de Geus-Oei |
Related Documents
:
|
17660664 - Profile of diabetic patients with end-stage renal failure requiring dialysis treatment ... 19293594 - Physical activity, high-density lipoprotein cholesterol subfractions and lecithin:chole... 17130274 - Inflammatory syndrome in patients on hemodialysis. 15991194 - Cardiac anomalies in patients with congenital diaphragmatic hernia and their prognosis:... 15759944 - Association of clinical and laboratory variables with ultrasound findings in right uppe... 646244 - Lymphocytic interstitial pneumonitis. review of 13 cases. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-22 |
Journal Detail:
|
Title: Cancer Volume: - ISSN: 0008-543X ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0374236 Medline TA: Cancer Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 American Cancer Society. |
Affiliation:
|
Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands. d.vriens@nucmed.umcn.nl. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rising incidence of second cancers in patients with low-risk (T1N0) thyroid cancer who receive radio...
Next Document: Sex and experience influence behavioral responses of adult rats to potentiated and nonpotentiated ul...