| The role of 1.5T cardiac MRI in the diagnosis, prognosis and management of pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 20336377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular magnetic imaging is a noninvasive, three dimensional tomographic technique that allows for a detailed morphology of the cardiac chambers, the accurate quantification of right ventricle volumes, myocardial mass, and transvalvular flow. It can also determine whether right ventricular diastolic function is impaired through pulmonary hypertension. The aim of this article is to review the main kinetic, morphological and functional changes of the right ventricle that can occur in patients affected by pulmonary arterial hypertension (PAH) and to assess how the MRI findings can influence the prognosis, and guide the decision-making strategy. In those cases in which MRI shows a significant cardiac diastolic dysfunction, the prognosis is predictive of pharmacological treatment failure, and mortality. This leaves double lung-heart transplantation as the only therapeutic option. The coexistence of PAH and left ventricle impairment causes worse right ventricle function, leads to a poor prognosis, and may change the therapeutic strategies (for example, PAH associated with left ventricle dysfunction may require a double lung-heart transplant). |
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Authors:
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Gianluca Marrone; Giuseppe Mamone; Angelo Luca; Patrizio Vitulo; Alessandro Bertani; Michele Pilato; Bruno Gridelli |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-25 |
Journal Detail:
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Title: The international journal of cardiovascular imaging Volume: 26 ISSN: 1875-8312 ISO Abbreviation: Int J Cardiovasc Imaging Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-07 Completed Date: 2010-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100969716 Medline TA: Int J Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 665-81 Citation Subset: IM |
Affiliation:
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Diagnostic and Interventional Radiology, Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Via Tricomi, Palermo, Italy. gmarrone@ismett.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Cardiovascular Agents / therapeutic use Contrast Media / diagnostic use Diagnosis, Differential Female Heart-Lung Transplantation Humans Hypertension, Pulmonary / complications, diagnosis*, physiopathology, therapy Magnetic Resonance Imaging, Cine* Male Middle Aged Predictive Value of Tests Treatment Outcome Ventricular Dysfunction, Left / complications, diagnosis Ventricular Dysfunction, Right / diagnosis*, etiology, physiopathology, therapy Ventricular Function, Right |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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