Document Detail

The role of 1.5T cardiac MRI in the diagnosis, prognosis and management of pulmonary arterial hypertension.
MedLine Citation:
PMID:  20336377     Owner:  NLM     Status:  MEDLINE    
Cardiovascular magnetic imaging is a noninvasive, three dimensional tomographic technique that allows for a detailed morphology of the cardiac chambers, the accurate quantification of right ventricle volumes, myocardial mass, and transvalvular flow. It can also determine whether right ventricular diastolic function is impaired through pulmonary hypertension. The aim of this article is to review the main kinetic, morphological and functional changes of the right ventricle that can occur in patients affected by pulmonary arterial hypertension (PAH) and to assess how the MRI findings can influence the prognosis, and guide the decision-making strategy. In those cases in which MRI shows a significant cardiac diastolic dysfunction, the prognosis is predictive of pharmacological treatment failure, and mortality. This leaves double lung-heart transplantation as the only therapeutic option. The coexistence of PAH and left ventricle impairment causes worse right ventricle function, leads to a poor prognosis, and may change the therapeutic strategies (for example, PAH associated with left ventricle dysfunction may require a double lung-heart transplant).
Gianluca Marrone; Giuseppe Mamone; Angelo Luca; Patrizio Vitulo; Alessandro Bertani; Michele Pilato; Bruno Gridelli
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-25
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  26     ISSN:  1875-8312     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-07     Completed Date:  2010-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  665-81     Citation Subset:  IM    
Diagnostic and Interventional Radiology, Mediterranean Institute of Transplantation and High Specialization Therapy (ISMETT), Via Tricomi, Palermo, Italy.
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MeSH Terms
Blood Pressure
Cardiovascular Agents / therapeutic use
Contrast Media / diagnostic use
Diagnosis, Differential
Heart-Lung Transplantation
Hypertension, Pulmonary / complications,  diagnosis*,  physiopathology,  therapy
Magnetic Resonance Imaging, Cine*
Middle Aged
Predictive Value of Tests
Treatment Outcome
Ventricular Dysfunction, Left / complications,  diagnosis
Ventricular Dysfunction, Right / diagnosis*,  etiology,  physiopathology,  therapy
Ventricular Function, Right
Reg. No./Substance:
0/Cardiovascular Agents; 0/Contrast Media

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