Document Detail


The rodent dominant lethal assay: a proposed format for data presentation that alerts to pseudo-dominant lethal effects.
MedLine Citation:
PMID:  7623866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rodent dominant lethal (DL) germ cell mutagenicity assay is the primary test for possible human germ cell mutagens. As such, it occupies a critical regulatory position. DL assay data are often difficult to assess because of the quantity of data involved, and because several related assay parameters require to be considered simultaneously. To reduce this difficulty a schematic method of data presentation is proposed and illustrated. This method enables the most pertinent assay data and parameters to be viewed and considered simultaneously. Using this format of data presentation, existing DL studies on cyclophosphamide, methylnitrosourea, diethylhexylphthalate, divinyl sulphone, methyl methanesulphonate, 6-mercaptopurine and ethylenethiourea are re-analysed.
Authors:
J Ashby; M J Clapp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  330     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-08-29     Completed Date:  1995-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  209-18     Citation Subset:  IM    
Affiliation:
Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Data Display / standards
Data Interpretation, Statistical
Dose-Response Relationship, Drug
Female
Fertility / drug effects
Fetal Death
Genes, Dominant
Genes, Lethal
Germ-Line Mutation*
Male
Mice
Mutagenicity Tests* / methods,  standards
Mutagens / toxicity*
Rats
Reproducibility of Results
Spermatozoa / drug effects
Chemical
Reg. No./Substance:
0/Mutagens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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