Document Detail

The risks of cancers of the colon and rectum in relation to coffee consumption.
MedLine Citation:
PMID:  2816900     Owner:  NLM     Status:  MEDLINE    
To assess whether recent coffee consumption is related to the incidence of large bowel cancer, the authors analyzed data from a multipurpose hospital-based case-control study of several cancers, conducted from 1978 to 1986 in Boston, Massachusetts, New York, New York, Philadelphia, Pennsylvania, and Baltimore, Maryland: 717 cases of colon cancer and 538 cases of rectal cancer were compared with 3,883 controls admitted for nonmalignant and malignant illnesses unrelated to coffee use. Relative risks were estimated by multiple logistic regression with allowance for age, sex, cigarette smoking, alcohol consumption, and several other potential confounding factors. Overall, relative to the consumption of one cup of coffee per day, the estimated relative risk of colon cancer for consumption of up to four cups per day in the period before admission was close to 1.0; for consumption of five or more cups per day, it was 0.6 (95% confidence interval 0.4-0.8). The results were consistent in men and women, and similar results were obtained whether the measure of consumption was use in the year before admission or use three years before admission. For rectal cancer, some relative risk estimates were elevated, particularly in men, but there was no consistent pattern of association, nor was there a trend of increasing risk with increasing consumption. The data suggest that recent coffee consumption is not related to an increased risks of large bowel cancer and that heavy coffee consumption may reduce the risk of colon cancer. A biologic rationale for such a reduction has not been established.
L Rosenberg; M M Werler; J R Palmer; D W Kaufman; M E Warshauer; P D Stolley; S Shapiro
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of epidemiology     Volume:  130     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-06     Completed Date:  1989-12-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  895-903     Citation Subset:  IM    
Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, MA 02146.
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MeSH Terms
Case-Control Studies
Coffee / adverse effects*
Colonic Neoplasms / epidemiology,  etiology*
Interviews as Topic
Middle Aged
Rectal Neoplasms / epidemiology,  etiology*
Regression Analysis
Risk Factors
United States
Grant Support
ED U 000082//PHS HHS; N01-CP-71029/CP/NCI NIH HHS; UO1 FD01222/FD/FDA HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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