| The risks and benefits of drug-eluting stents in the setting of STEMI. | |
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MedLine Citation:
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PMID: 18715537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary percutaneous coronary intervention (PCI) represents the treatment of choice in patients with ST-segment elevation myocardial infarction (STEMI). In randomized trials excluding STEMI patients, using drug-eluting stents (DES) significantly reduced angiographic restenosis and target vessel revascularization compared with bare metal stents (BMS); however, concerns exist regarding an increased follow-up incidence of stent thrombosis after DES implantation. This complication, which is associated with higher mortality and morbidity rates, may be more frequent among STEMI patients receiving DES versus BMS. Various registries, randomized trials, and two recent meta-analyses on patients undergoing primary PCI have shown that using DES is safe and is associated with significantly reduced rates of restenosis and repeat intervention without an increased risk of myocardial infarction or stent thrombosis at intermediate-term follow-up. However, large trials with hard clinical end points and longer follow-up are needed before routine DES use can be recommended in patients undergoing primary PCI. |
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Authors:
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Rosetta Melfi; Annunziata Nusca; Giuseppe Patti; Germano Di Sciascio |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current cardiology reports Volume: 10 ISSN: 1534-3170 ISO Abbreviation: Curr Cardiol Rep Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-21 Completed Date: 2008-12-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888969 Medline TA: Curr Cardiol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 402-6 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Sciences, Campus Bio-Medico University, Via Alvaro del Portillo 200, 00128, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Drug-Eluting Stents* / adverse effects Humans Meta-Analysis as Topic Metals Myocardial Infarction / therapy* Randomized Controlled Trials as Topic Thrombosis / etiology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Metals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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