Document Detail


The risk of unintended pregnancies in users of the contraceptive patch compared to users of oral contraceptives in the UK General Practice Research Database.
MedLine Citation:
PMID:  19631789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The transdermal contraceptive patch EVRA has been marketed since 2002 as an alternative to oral contraceptives (OCs), but large follow-up studies of effectiveness are lacking. STUDY DESIGN: We used a cohort plus a nested case-control study to estimate rates and hazard ratios of unintended pregnancy among users of different hormonal contraceptives (HC) and to evaluate the effects of various potential predictors on unintended pregnancy. RESULTS: Rates of unintended pregnancy were all low (overall rate 0.17 per 100 women-years), though they were slightly higher in users of progestogen-only OCs and EVRA compared to users of second-generation OCs. The hazard ratios for unintended pregnancy were also higher for users of progestogen-only OCs and the patch compared to users of second-generation OCs, although these estimates may be confounded by compliance. Rates of unintended pregnancy were inversely associated with age and duration of HC use as well as with other predictors of pregnancy but not body mass index or use of antibiotics. CONCLUSION: The rates of unintended pregnancy were low for all study HCs, and while the data on unintended pregnancy in EVRA users compared to OC users are sufficient to rule out major differences in the rate of unintended pregnancy, they are not sufficient to rule out modest ones.
Authors:
Susan S Jick; Katrina W Hagberg; James A Kaye; Hershel Jick
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-25
Journal Detail:
Title:  Contraception     Volume:  80     ISSN:  1879-0518     ISO Abbreviation:  Contraception     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  142-51     Citation Subset:  IM    
Affiliation:
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA. sjick@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adolescent
Adult
Case-Control Studies
Contraceptives, Oral, Combined*
Databases, Factual
Ethinyl Estradiol / administration & dosage*
Ethinyl Estradiol-Norgestrel Combination*
Female
Great Britain
Humans
Norgestrel / administration & dosage,  analogs & derivatives*
Pregnancy
Pregnancy, Unwanted*
Proportional Hazards Models
Young Adult
Chemical
Reg. No./Substance:
0/Contraceptives, Oral, Combined; 0/Ortho Evra; 57-63-6/Ethinyl Estradiol; 6533-00-2/Norgestrel; 8056-51-7/Ethinyl Estradiol-Norgestrel Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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