Document Detail

The risk of human immunodeficiency virus-1 infection in twin pairs born to infected mothers in Africa.
MedLine Citation:
PMID:  12964116     Owner:  NLM     Status:  MEDLINE    
We examined birth order and delivery route as risk factors for mother-to-child transmission of human immunodeficiency virus (HIV)-1 in 315 twin pairs born in Malawi during 1994-1998. No antiretroviral drugs were administered to these subjects. Infections were detected by polymerase chain reaction and were stratified as having occurred either in utero, perinatally, or postnatally. Risk of in utero infection for 630 infants (39 infections) did not differ by birth order (first born, 6.3%; second born, 6.0%). Similarly, in 260 vaginally delivered infants evaluated for perinatal infection (45 infections), risk did not differ by birth order (first born, 15.9%; second born, 18.7%); risk of perinatal infection was significantly lower in cesarean-delivered infants (odds ratio, 0.19 [95% confidence interval, 0.02-0.78]). There was no effect on postnatal transmission rates. Thus, in contrast to the authors of earlier studies, we did not find birth order to be an important risk factor for infection in twins. These findings indicate that birth-canal exposure is not a major contributor to a newborn's risk of HIV-1 infection.
Robert J Biggar; Sharon Cassol; Newton Kumwenda; Valentino Lema; Michelle Janes; Richard Pilon; Vincent Senzani; Frances Yellin; Taha E T Taha; Robin L Broadhead
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Publication Detail:
Type:  Journal Article     Date:  2003-09-09
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  188     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-09     Completed Date:  2003-10-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  850-5     Citation Subset:  AIM; IM    
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
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MeSH Terms
Birth Order
Cesarean Section
Delivery, Obstetric / methods
Diseases in Twins*
HIV Infections / transmission*
HIV-1* / isolation & purification
Infant, Newborn
Infectious Disease Transmission, Vertical*
Pregnancy Complications, Infectious / virology
Pregnancy, Multiple
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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