| A rise in ambient temperature augments insulin absorption in diabetic patients. | |
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MedLine Citation:
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PMID: 7010077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The absorption rate of 125I-Actrapid insulin (6 U) from a subcutaneous injection site was examined in six insulin-dependent diabetic patients at ambient temperatures of 20 degrees C and 35 degrees C. During a 4-hr observation period, the insulin disappearance rate at 35 degrees C was 50%-60% greater than at 20 degrees C (p less than 0.01). Despite the small dose of insulin used, plasma glucose levels tended to be 1 to 2 mmole/liter lower at 35 degrees C than at 20 degrees C. These findings indicate that a rise in ambient temperature augments insulin absorption, in insulin-treated diabetic patients. |
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Authors:
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V A Koivisto; S Fortney; R Hendler; P Felig |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 30 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1981 Apr |
Date Detail:
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Created Date: 1981-05-21 Completed Date: 1981-05-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 402-5 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adult Blood Glucose / metabolism Diabetes Mellitus / drug therapy* Hot Temperature* Humans Insulin / metabolism*, therapeutic use Kinetics Male Skin Temperature* |
| Grant Support | |
ID/Acronym/Agency:
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AM13526/AM/NIADDK NIH HHS; RR125/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 12584-58-6/insulin, neutral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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