Document Detail


The rise and fall of long-lived humoral immunity: terminal differentiation of plasma cells in health and disease.
MedLine Citation:
PMID:  12846808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-lived humoral immune responses are a hallmark of thymus-dependent immunity. The cellular basis for enduring antibody-mediated immunity is long-lived memory B cells and plasma cells (PCs). Both of these cell populations acquire longevity as a result of antigen-specific, CD40-dependent, cognate interactions with helper T cells within germinal centers (GCs). At the molecular level, defined functional domains of CD40 control the post-GC fate of B cells. PC precursors that emerge from these GC reactions are highly proliferative and terminally differentiate to end-stage cells within the bone marrow (BM). The striking phenotypic similarities between the PC precursors and the putative malignant cell in multiple myeloma (MM) suggests that MM may result from the transformation of PC precursors. Within the domain of autoimmune disease, recent studies have shown that dysregulated migration of PCs to the BM may impact immune homeostasis and the development of lupus. Understanding the processes of normal PC differentiation will provide strategic insights into identifying therapeutic targets for the treatment of differentiated B-cell disorders.
Authors:
Brian P O'Connor; Michael W Gleeson; Randolph J Noelle; Loren D Erickson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  194     ISSN:  0105-2896     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-08     Completed Date:  2004-03-10     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  61-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation*
Cell Differentiation*
Disease*
Health*
Humans
Multiple Myeloma / immunology,  pathology
Plasma Cells / cytology*,  immunology*,  pathology
Grant Support
ID/Acronym/Agency:
AI026296/AI/NIAID NIH HHS; AI048667/AI/NIAID NIH HHS; AI049580/AI/NIAID NIH HHS; AI052211/AI/NIAID NIH HHS; CA082542/CA/NCI NIH HHS; R01 AI026296/AI/NIAID NIH HHS; R01 AI026296-09/AI/NIAID NIH HHS; R01 AI048667/AI/NIAID NIH HHS; R01 AI048667-01/AI/NIAID NIH HHS; R01 AI049580/AI/NIAID NIH HHS; R01 AI049580-01/AI/NIAID NIH HHS; R01 AI052211/AI/NIAID NIH HHS; R01 AI052211-01/AI/NIAID NIH HHS; R01 CA082542/CA/NCI NIH HHS; R01 CA082542-01/CA/NCI NIH HHS
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