Document Detail


The rigidity of repaired flexor tendons increases following ex vivo cyclic loading.
MedLine Citation:
PMID:  12021007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transected flexor tendons are typically treated by suture repair followed by rehabilitation that generates repetitive tendon loading. Recent results in an in vivo canine model indicate that during the first 10 days after injury and repair, there is an increase in the rigidity of the tendon repair site. Our objective was to determine whether or not ex vivo cyclic loading of repaired flexor tendons causes a similar increase in repair-site rigidity. We simulated 10 days of rehabilitation by applying 6000 loading cycles to repaired canine flexor tendons ex vivo at force levels generated during passive motion rehabilitation; we then evaluated their tensile mechanical properties. High-force (peak force, 17 N) cyclic loading increased repair-site rigidity by 100% and decreased repair-site strain by 50%, whereas low-force (5 N) loading did not change the properties of the repair site. This mechanical conditioning effect may explain, in part, the changes in tensile properties observed after only 10 days of healing in vivo. Mechanical conditioning of repaired flexor tendons by repetitive forces applied during rehabilitation may lead to increases in repair-site rigidity and decreases in strain, thereby altering the mechanical loading environment of tissues and cells at the repair site.
Authors:
Konstantinos T Ditsios; Meghan E Burns; Martin I Boyer; Richard H Gelberman; Matthew J Silva
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biomechanics     Volume:  35     ISSN:  0021-9290     ISO Abbreviation:  J Biomech     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-21     Completed Date:  2002-11-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  853-6     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, Washington University, Suite 11300, 1 Barnes-Jewish Plaza, St. Louis, MO 63100, USA. ditsiosk@msnotes.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cadaver
Dogs
Elasticity
Hindlimb / physiopathology
Periodicity
Postoperative Complications / physiopathology*
Reference Values
Sensitivity and Specificity
Stress, Mechanical
Suture Techniques
Sutures
Tendon Injuries / etiology,  physiopathology*,  rehabilitation,  surgery*
Tendons / physiopathology*,  surgery
Weight-Bearing
Wound Healing / physiology*
Grant Support
ID/Acronym/Agency:
AR33097/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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